{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:47:38Z","timestamp":1791107258330,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:p>At present, the human Factor H protein family represents seven multidomain, multifunctional serum proteins. This group includes the complement and immune regulators Factor H, the Factor H-like protein 1 (FHL-1) and five Factor H-related proteins proteins (FHR-1, -2, -3, -4 and -5). Each is exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. Structure-function analyses allowed the localization of the complement regulatory domain of Factor H and FHL-1 in the N-terminal region within SCRs 1\u20134. In addition, multiple binding sites for C3b, heparin and microbial surface proteins were localized in the N-terminus, within the middle region and also in the C-terminus of Factor H and FHL-1. Recent results show a central role for the C-terminus of Factor H, i.e. SCRs 19\u201320. These particular domains are conserved in all FHRs identified so far, include contact points for C3b, heparin and microbial surface proteins and represent a \u2018hot-spot\u2019 for gene mutations in patients that suffer from the Factor H-associated form of haemolytic uraemic syndrome.<\/jats:p>","DOI":"10.1042\/bst0300971","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T09:40:05Z","timestamp":1088070005000},"page":"971-978","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":195,"title":["Factor H family proteins: on complement, microbes and human diseases"],"prefix":"10.1042","volume":"30","author":[{"given":"P. F.","family":"Zipfel","sequence":"first","affiliation":[{"name":"Hans Knoell Institute for Natural Products Research, Beutenbergstrasse I la, D-07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Skerka","sequence":"additional","affiliation":[{"name":"Hans Knoell Institute for Natural Products Research, Beutenbergstrasse I la, D-07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hellwage","sequence":"additional","affiliation":[{"name":"Hans Knoell Institute for Natural Products Research, Beutenbergstrasse I la, D-07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Jokiranta","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, Haartmaninkatu 3, University of Helsinki, FIN-00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meri","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, Haartmaninkatu 3, University of Helsinki, FIN-00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Brade","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Frankfurt University Hospital, Paul-Ehrlich-Str. 40, D-60596 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kraiczy","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Frankfurt University Hospital, Paul-Ehrlich-Str. 40, D-60596 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Noris","sequence":"additional","affiliation":[{"name":"Mario Negri Institute for Pharmacological Research, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Remuzzi","sequence":"additional","affiliation":[{"name":"Mario Negri Institute for Pharmacological Research, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/30\/6\/971\/509869\/bst0300971.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/30\/6\/971\/509869\/bst0300971.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T20:09:59Z","timestamp":1637179799000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/30\/6\/971\/63717\/Factor-H-family-proteins-on-complement-microbes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bst0300971","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,1]]}}}