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Coupled with these observations, parkin may integrate other gene products associated with parkinsonism, including \u03b1-synuclein, LRRK2 (leucine-rich repeat kinase 2), DJ-1 and PINK1 [PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced putative kinase 1], into a common biochemical pathway of potential relevance to disease pathogenesis. Parkin therefore represents a unique multifaceted ubiquitin ligase consistent with an important housekeeping role in maintaining the integrity or survival of dopaminergic neurons.<\/jats:p>","DOI":"10.1042\/bst0340749","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T13:28:26Z","timestamp":1161782906000},"page":"749-753","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Parkin: a multifaceted ubiquitin ligase"],"prefix":"10.1042","volume":"34","author":[{"given":"D.J.","family":"Moore","sequence":"first","affiliation":[{"name":"Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Broadway Research Building, Suite 731, Baltimore, MD 21205, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2006,10,25]]},"reference":[{"key":"2021111720111025100_B1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.neuro.28.061604.135718","volume":"28","author":"Moore","year":"2005","journal-title":"Annu. 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