{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T18:00:27Z","timestamp":1694628027147},"reference-count":54,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:p>Increasing prevalence of obesity combined with longevity will produce an epidemic of Type 2 (non-insulin-dependent) diabetes in the next 20\u00a0years. This disease is associated with defects in insulin secretion, specifically abnormalities of insulin secretory kinetics and pancreatic \u03b2-cell glucose responsiveness. Mechanisms underlying \u03b2-cell dysfunction include glucose toxicity, lipotoxicity and \u03b2-cell hyperactivity. Defects at various sites in \u03b2-cell signal transduction pathways contribute, but no single lesion can account for the common form of Type 2 diabetes. Recent studies highlight diverse \u03b2-cell actions of GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). These intestinal hormones target the \u03b2-cell to stimulate glucose-dependent insulin secretion through activation of protein kinase A and associated pathways. Both increase gene expression and proinsulin biosynthesis, protect against apoptosis and stimulate replication\/neogenesis of \u03b2-cells. Incretin hormones therefore represent an exciting future multi-action solution to correct \u03b2-cell defect in Type 2 diabetes.<\/jats:p>","DOI":"10.1042\/bst0340774","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T13:28:26Z","timestamp":1161782906000},"page":"774-778","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nutrient regulation of pancreatic \u03b2-cell function in diabetes: problems and potential solutions"],"prefix":"10.1042","volume":"34","author":[{"given":"P.R.","family":"Flatt","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.D.","family":"Green","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Queens University Belfast, Belfast BT9 5AG, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2006,10,25]]},"reference":[{"key":"2021111720104470900_B1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0098-2997(01)00013-9","volume":"22","author":"Rutter","year":"2001","journal-title":"Mol. 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