{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:02:36Z","timestamp":1762160556437},"reference-count":34,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:p>In several experimental studies of cerebral ischaemia, G-CSF (granulocyte colony-stimulating factor) exerted neuroprotective effects through different mechanisms, including mobilization of haemopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti-inflammation. Hence, G-CSF not only inhibits neuron death, but also generates \u2018new\u2019 neural tissue formation. A small pilot trial reports on the safety and feasibility of G-CSF therapy in stroke patients. According to this evidence, we can speculate that G-CSF, being used either alone or in combination with another agent, should have a dual activity beneficial both to acute neuronal protection and long-term plasticity after cerebral ischaemia, thus proposing that G-CSF is an ideal new drug for stroke and neurodegenerative diseases.<\/jats:p>","DOI":"10.1042\/bst0341327","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T12:24:03Z","timestamp":1162556643000},"page":"1327-1333","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia"],"prefix":"10.1042","volume":"34","author":[{"given":"C.-Z.","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Institute of Brain Science, University of Fudan, 12 Middle Wulumuqi Road, 200040 Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.-G.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Institute of Brain Science, University of Fudan, 12 Middle Wulumuqi Road, 200040 Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2006,10,25]]},"reference":[{"key":"2021111720210875000_B1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1368-5031.2006.00873.x","volume":"60","author":"Davis","year":"2006","journal-title":"Int. J. Clin. Pract."},{"key":"2021111720210875000_B2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/01.STR.0000056944.42686.1E","volume":"34","author":"Katzan","year":"2003","journal-title":"Stroke"},{"key":"2021111720210875000_B3","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1161\/01.STR.0000226651.04862.da","volume":"37","author":"Weintraub","year":"2006","journal-title":"Stroke"},{"key":"2021111720210875000_B4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neulet.2005.10.040","volume":"394","author":"Jung","year":"2006","journal-title":"Neurosci. Lett."},{"key":"2021111720210875000_B5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/sj.jcbfm.9600195","volume":"26","author":"Komine-Kobayashi","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2021111720210875000_B6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainres.2005.07.076","volume":"1058","author":"Lee","year":"2005","journal-title":"Brain Res."},{"key":"2021111720210875000_B7","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1172\/JCI23559","volume":"115","author":"Schneider","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2021111720210875000_B8","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1161\/01.STR.0000057814.70180.17","volume":"34","author":"Schabitz","year":"2003","journal-title":"Stroke"},{"key":"2021111720210875000_B9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainres.2006.02.140","volume":"1098","author":"Zhao","year":"2006","journal-title":"Brain Res."},{"key":"2021111720210875000_B10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/CIRCULATIONAHA.105.563668","volume":"113","author":"Kawada","year":"2006","journal-title":"Circulation"},{"key":"2021111720210875000_B11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1503\/cmaj.051322","volume":"174","author":"Shyu","year":"2006","journal-title":"Can. Med. Assoc. J."},{"key":"2021111720210875000_B12","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1503\/cmaj.060199","volume":"174","author":"Borlongan","year":"2006","journal-title":"Can. Med. Assoc. J."},{"key":"2021111720210875000_B13","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1161\/01.CIR.0000142616.07367.66","volume":"110","author":"Shyu","year":"2004","journal-title":"Circulation"},{"key":"2021111720210875000_B14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0014-2999(02)02785-1","volume":"458","author":"Six","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"2021111720210875000_B15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"2021111720210875000_B16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1212\/WNL.59.4.514","volume":"59","author":"Li","year":"2002","journal-title":"Neurology"},{"key":"2021111720210875000_B17","doi-asserted-by":"crossref","first-page":"10344","DOI":"10.1073\/pnas.181177898","volume":"98","author":"Orlic","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720210875000_B18","doi-asserted-by":"crossref","first-page":"I186","DOI":"10.1161\/CIRCULATIONAHA.105.001610","volume":"114","author":"Mieno","year":"2006","journal-title":"Circulation"},{"key":"2021111720210875000_B19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF02983240","volume":"78","author":"Hirayama","year":"2003","journal-title":"Int. J. Hematol."},{"key":"2021111720210875000_B20","doi-asserted-by":"crossref","first-page":"9231","DOI":"10.1073\/pnas.83.23.9231","volume":"83","author":"Williams","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720210875000_B21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3727\/096020198389933","volume":"11","author":"Tate","year":"2002","journal-title":"Cell Transplant"},{"key":"2021111720210875000_B22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/85426","volume":"7","author":"Mosher","year":"2001","journal-title":"Nat. Med."},{"key":"2021111720210875000_B23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/85471","volume":"7","author":"Sakai","year":"2001","journal-title":"Nat. Med."},{"key":"2021111720210875000_B24","doi-asserted-by":"crossref","first-page":"9282","DOI":"10.1523\/JNEUROSCI.2120-04.2004","volume":"24","author":"Tom","year":"2004","journal-title":"J. Neurosci."},{"key":"2021111720210875000_B25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nm1199","volume":"11","author":"Harada","year":"2005","journal-title":"Nat. Med."},{"key":"2021111720210875000_B26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/jnen\/62.4.329","volume":"62","author":"Ferrer","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2021111720210875000_B27","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1096\/fj.04-3496fje","volume":"19","author":"Ohki","year":"2005","journal-title":"FASEB J."},{"key":"2021111720210875000_B28","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1182\/blood-2006-04-013755","volume":"108","author":"Capoccia","year":"2006","journal-title":"Blood"},{"key":"2021111720210875000_B29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1254\/jphs.FP0040966","volume":"99","author":"Takagi","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"2021111720210875000_B30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1634\/stemcells.2004-0190","volume":"23","author":"Minamino","year":"2005","journal-title":"Stem. Cells"},{"key":"2021111720210875000_B31","doi-asserted-by":"crossref","first-page":"918","DOI":"10.4049\/jimmunol.149.3.918","volume":"149","author":"Gorgen","year":"1992","journal-title":"J. Immunol."},{"key":"2021111720210875000_B32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/sj.bjp.0700904","volume":"120","author":"Squadrito","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"2021111720210875000_B33","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/00003246-199905000-00051","volume":"27","author":"Heard","year":"1999","journal-title":"Crit. Care Med."},{"key":"2021111720210875000_B34","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/01.jnen.0000179196.10032.dd","volume":"64","author":"Gibson","year":"2005","journal-title":"J. Neuropathol Exp. Neurol."}],"container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/34\/6\/1327\/546832\/bst0341327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/34\/6\/1327\/546832\/bst0341327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T02:00:03Z","timestamp":1707357603000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/34\/6\/1327\/66098\/G-CSF-and-neuroprotection-a-therapeutic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,25]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,10,25]]},"published-print":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bst0341327","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,25]]}}}