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As a result of disease, however, hypertrophy progresses to a decompensated state and Ca2+ signalling capacity and cardiac output are reduced. Here, the role that Ca2+ plays in the induction of hypertrophy as well as the impact that cardiac hypertrophy and failure has on Ca2+ fluxes will be discussed.<\/jats:p>","DOI":"10.1042\/bst0350957","type":"journal-article","created":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T11:09:43Z","timestamp":1193915383000},"page":"957-961","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid"],"prefix":"10.1042","volume":"35","author":[{"given":"H.L.","family":"Roderick","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, U.K."},{"name":"Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Higazi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Smyrnias","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fearnley","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Harzheim","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Bootman","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2007,10,25]]},"reference":[{"key":"2021111900120307000_B1","volume-title":"Coronary Heart Disease Statistics","author":"Allender","year":"2006"},{"key":"2021111900120307000_B2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0002-9629(15)40499-9","volume":"317","author":"Benjamin","year":"1999","journal-title":"Am. 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