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A method for the in situ measurement of the electrical potential across the phagosomal membrane is described. In addition, we discuss the finding that acidification is not only a consequence, but also a critical determinant of phagosome maturation. Luminal acidification appears to function as a timing device controlling the transition between early and late phagosomes.<\/jats:p>","DOI":"10.1042\/bst0351083","type":"journal-article","created":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T11:09:43Z","timestamp":1193915383000},"page":"1083-1087","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Phagosomal acidification: measurement, manipulation and functional consequences"],"prefix":"10.1042","volume":"35","author":[{"given":"B.E.","family":"Steinberg","sequence":"first","affiliation":[{"name":"Cell Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, M5S 1A8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.","family":"Huynh","sequence":"additional","affiliation":[{"name":"Cell Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8"},{"name":"Department of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Grinstein","sequence":"additional","affiliation":[{"name":"Cell Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, M5S 1A8"},{"name":"Department of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2007,10,25]]},"reference":[{"key":"2021111900292287900_B1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1042\/bj20020691","volume":"366","author":"Vieira","year":"2002","journal-title":"Biochem. 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