{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:09:18Z","timestamp":1791295758532,"version":"4.1.0"},"reference-count":18,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:p>Overexpression of the enzyme COX-2 (cyclo-oxygenase-2) is associated with various pathophysiological conditions, including inflammatory diseases and different cancers. Increased synthesis of COX-2 in fetal membranes and the myometrium is also linked with the onset of term and preterm labour. COX-2 gene regulation is controlled at various levels including gene transcription and post-transcriptional events. The present article focuses on the complexity of COX-2 gene regulation and reviews current concepts that highlight: (i) transcription of COX-2 is induced rapidly and transiently in response to a plethora of stimuli; (ii) COX-2 mRNA stability and translational efficiency is governed by multiple regulatory elements within the 3\u2032-untranslated region; (iii) specific microRNAs and RNA-binding proteins influence COX-2 mRNA stability; and (iv) regulation of COX-2 involves alternative polyadenylation.<\/jats:p>","DOI":"10.1042\/bst0360543","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T13:27:46Z","timestamp":1213190866000},"page":"543-545","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Complexity of <i>COX<\/i>-<i>2<\/i> gene regulation"],"prefix":"10.1042","volume":"36","author":[{"given":"Kelly\u00a0A.","family":"Harper","sequence":"first","affiliation":[{"name":"Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison\u00a0J.","family":"Tyson-Capper","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"2021111720264000400_B1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/sj.bjp.0702897","article-title":"Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy","volume":"128","author":"Mitchell","year":"1999","journal-title":"Br. 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