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Mutations in the human MECP2 gene cause the autism spectrum disorder Rett Syndrome. MeCP2 is most highly expressed in neurons, and mice lacking this protein show symptoms that strikingly parallel those of Rett patients. Surprisingly, these symptoms are efficiently reversed by delayed activation of a \u2018stopped\u2019 Mecp2 gene, raising hopes that human Rett syndrome may also be reversible. Future studies of MeCP2 promise to shed light upon brain function, neurological disease and the biology of DNA methylation.<\/jats:p>","DOI":"10.1042\/bst0360575","type":"journal-article","created":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T09:19:59Z","timestamp":1216718399000},"page":"575-583","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The methyl-CpG-binding protein MeCP2 and neurological disease"],"prefix":"10.1042","volume":"36","author":[{"given":"Adrian","family":"Bird","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, The King's Buildings, Edinburgh EH9 3JR, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2008,7,22]]},"reference":[{"key":"2021111719101510500_B1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1101\/sqb.2004.69.113","article-title":"Reading the DNA methylation signal","volume":"69","author":"Bird","year":"2004","journal-title":"Cold Spring Harbor Symp. 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