{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T12:45:38Z","timestamp":1746794738855},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:p>miRNAs (microRNAs) are important regulatory molecules that control gene expression in all eukaryotes. miRNAs play an essential role in basic cellular activities such as proliferation, differentiation, morphogenesis and apoptosis. In haemopoiesis, several miRNA-based pathways have been identified. Importantly, miRNA mutations or mis-expression correlate with various human diseases. In cancer, deregulated miRNAs can function as tumour suppressors or oncogenes. The present review focuses on the recent literature concerning the role of miRNAs in three different research areas: haematology, cardiology and oncology, with particular focus on the results obtained by our group.<\/jats:p>","DOI":"10.1042\/bst0361206","type":"journal-article","created":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T17:27:13Z","timestamp":1228238833000},"page":"1206-1210","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of microRNAs in haemopoiesis, heart hypertrophy and cancer"],"prefix":"10.1042","volume":"36","author":[{"given":"Laura","family":"Fontana","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Condorelli","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, via Milanese 300, 20099 Sesto San Giovanni, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Peschle","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"},{"name":"IRCCS MultiMedica, via Milanese 300, 20099 Sesto San Giovanni, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2008,11,19]]},"reference":[{"key":"2021111720413387500_B1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"2021111720413387500_B2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2021111720413387500_B3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/gad.1399806","article-title":"Control of translation and mRNA degradation by miRNAs and siRNAs","volume":"20","author":"Valencia-Sanchez","year":"2006","journal-title":"Genes Dev."},{"key":"2021111720413387500_B4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tibs.2007.02.006","article-title":"A developmental view of microRNA function","volume":"32","author":"Zhao","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"2021111720413387500_B5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nrc2232","article-title":"MicroRNAs join the p53 network: another piece in the tumour-suppression puzzle","volume":"7","author":"He","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"2021111720413387500_B6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nri2024","article-title":"Transcription factors in myeloid development: balancing differentiation with transformation","volume":"7","author":"Rosenbauer","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2021111720413387500_B7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1091903","article-title":"MicroRNAs modulate hematopoietic lineage differentiation","volume":"303","author":"Chen","year":"2004","journal-title":"Science"},{"key":"2021111720413387500_B8","doi-asserted-by":"crossref","first-page":"18081","DOI":"10.1073\/pnas.0506216102","article-title":"MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation","volume":"102","author":"Felli","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1182\/blood-2007-05-092718","article-title":"MicroRNA miR-24 inhibits erythropoiesis by targeting activin type\u00a0I receptor ALK4","volume":"111","author":"Wang","year":"2008","journal-title":"Blood"},{"key":"2021111720413387500_B10","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1073\/pnas.0712312105","article-title":"A GATA-1-regulated microRNA locus essential for erythropoiesis","volume":"105","author":"Dore","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B11","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.devcel.2008.03.012","article-title":"MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors","volume":"14","author":"Lu","year":"2008","journal-title":"Dev. Cell"},{"key":"2021111720413387500_B12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/ncb1741","article-title":"A three-step pathway comprising PLZF\/miR-146a\/CXCR4 controls megakaryopoiesis","volume":"10","author":"Labbaye","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2021111720413387500_B13","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-\u03baB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B14","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tcb.2006.09.003","article-title":"POZ for effect: POZ-ZF transcription factors in cancer and development","volume":"16","author":"Kelly","year":"2006","journal-title":"Trends Cell Biol."},{"key":"2021111720413387500_B15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ncb1613","article-title":"MicroRNAs 17-5p\u201320a\u2013106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation","volume":"9","author":"Fontana","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2021111720413387500_B16","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J."},{"key":"2021111720413387500_B17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jmb.2004.03.065","article-title":"Molecular evolution of a microRNA cluster","volume":"339","author":"Tanzer","year":"2004","journal-title":"J. Mol. Biol."},{"key":"2021111720413387500_B18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","article-title":"Targeted deletion reveals essential and overlapping functions of the miR-17\u223c92 family of miRNA clusters","volume":"132","author":"Ventura","year":"2008","journal-title":"Cell"},{"key":"2021111720413387500_B19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ni1575","article-title":"Lymphoproliferative disease and autoimmunity in mice with increased miR-17\u201392 expression in lymphocytes","volume":"9","author":"Xiao","year":"2008","journal-title":"Nat. Immunol."},{"key":"2021111720413387500_B20","doi-asserted-by":"crossref","first-page":"19849","DOI":"10.1073\/pnas.0706963104","article-title":"The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte\/macrophage differentiation","volume":"104","author":"Rosa","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B21","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response","volume":"104","author":"O'Connell","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B22","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.20072108","article-title":"Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder","volume":"205","author":"O'Connell","year":"2008","journal-title":"J. Exp. Med."},{"key":"2021111720413387500_B23","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.1141229","article-title":"Regulation of the germinal center response by microRNA-155","volume":"316","author":"Thai","year":"2007","journal-title":"Science"},{"key":"2021111720413387500_B24","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function","volume":"316","author":"Rodriguez","year":"2007","journal-title":"Science"},{"key":"2021111720413387500_B25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2007.10.009","article-title":"MicroRNA-155 regulates the generation of immunoglobulin class-switched plasma cells","volume":"27","author":"Vigorito","year":"2007","journal-title":"Immunity"},{"key":"2021111720413387500_B26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nature06607","article-title":"Regulation of progenitor cell proliferation and granulocyte function by microRNA-223","volume":"451","author":"Johnnidis","year":"2008","journal-title":"Nature"},{"key":"2021111720413387500_B27","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cell.2005.09.023","article-title":"A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C\/EBP\u03b1 regulates human granulopoiesis","volume":"123","author":"Fazi","year":"2005","journal-title":"Cell"},{"key":"2021111720413387500_B28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"Care","year":"2007","journal-title":"Nat. Med."},{"key":"2021111720413387500_B29","doi-asserted-by":"crossref","first-page":"18255","DOI":"10.1073\/pnas.0608791103","article-title":"A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure","volume":"103","author":"van\u00a0Rooij","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs: microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"2021111720413387500_B31","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","article-title":"Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers","volume":"101","author":"Calin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B32","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature06174","article-title":"Tumour invasion and metastasis initiated by microRNA-10b in breast cancer","volume":"449","author":"Ma","year":"2007","journal-title":"Nature"},{"key":"2021111720413387500_B33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nature06487","article-title":"Endogenous human microRNAs that suppress breast cancer metastasis","volume":"451","author":"Tavazoie","year":"2008","journal-title":"Nature"},{"key":"2021111720413387500_B34","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ncb1681","article-title":"The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis","volume":"10","author":"Huang","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2021111720413387500_B35","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nature05939","article-title":"A microRNA component of the p53 tumour suppressor network","volume":"447","author":"He","year":"2007","journal-title":"Nature"},{"key":"2021111720413387500_B36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.molcel.2007.05.017","article-title":"Transcriptional activation of miR-34a contributes to p53-mediated apoptosis","volume":"26","author":"Raver-Shapira","year":"2007","journal-title":"Mol. Cell"},{"key":"2021111720413387500_B37","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cub.2007.06.068","article-title":"p53-mediated activation of miRNA34 candidate tumor-suppressor genes","volume":"17","author":"Bommer","year":"2007","journal-title":"Curr. Biol."},{"key":"2021111720413387500_B38","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2007.05.010","article-title":"Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis","volume":"26","author":"Chang","year":"2007","journal-title":"Mol. Cell"},{"key":"2021111720413387500_B39","doi-asserted-by":"crossref","first-page":"15472","DOI":"10.1073\/pnas.0707351104","article-title":"Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells","volume":"104","author":"Tazawa","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B40","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1038\/sj.onc.1210293","article-title":"MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells","volume":"26","author":"Welch","year":"2007","journal-title":"Oncogene"},{"key":"2021111720413387500_B41","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","article-title":"A microRNA polycistron as a potential human oncogene","volume":"435","author":"He","year":"2005","journal-title":"Nature"},{"key":"2021111720413387500_B42","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/ng1855","article-title":"Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster","volume":"38","author":"Dews","year":"2006","journal-title":"Nat. Genet."},{"key":"2021111720413387500_B43","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720413387500_B44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"MicroRNAs as oncogenes and tumor suppressors","volume":"302","author":"Zhang","journal-title":"Dev. Biol."},{"key":"2021111720413387500_B45","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ccr.2008.02.013","article-title":"E2F1-regulated microRNAs impair TGF\u03b2-dependent cell-cycle arrest and apoptosis in gastric cancer","volume":"13","author":"Petrocca","year":"2008","journal-title":"Cancer Cell"},{"key":"2021111720413387500_B46","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1158\/0008-5472.CAN-05-2352","article-title":"A polycistronic microRNA cluster, miR-17\u201392, is overexpressed in human lung cancers and enhances cell proliferation","volume":"65","author":"Hayashita","year":"2005","journal-title":"Cancer Res."},{"key":"2021111720413387500_B47","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature03677","article-title":"c-Myc-regulated microRNAs modulate E2F1 expression","volume":"435","author":"O'Donnell","year":"2005","journal-title":"Nature"},{"key":"2021111720413387500_B48","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1074\/jbc.M608939200","article-title":"An E2F\/miR-20a autoregulatory feedback loop","volume":"282","author":"Sylvestre","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021111720413387500_B49","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1074\/jbc.C600252200","article-title":"Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors","volume":"282","author":"Woods","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021111720413387500_B50","doi-asserted-by":"crossref","first-page":"e2236","DOI":"10.1371\/journal.pone.0002236","article-title":"Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM","volume":"3","author":"Fontana","year":"2008","journal-title":"PLoS ONE"}],"container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/36\/6\/1206\/852914\/bst0361206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/36\/6\/1206\/852914\/bst0361206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T01:01:56Z","timestamp":1637197316000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/36\/6\/1206\/66706\/Role-of-microRNAs-in-haemopoiesis-heart"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,19]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,11,19]]},"published-print":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bst0361206","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,19]]}}}