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However, the molecular mechanism through which BRCA1 functions to preserve genome stability remains unclear. In the present article, we examine the different ways in which BRCA1 might influence the repair of DNA damage and the preservation of genome integrity, taking into account what is currently known about its interactions with other proteins, its biochemical activity and its nuclear localization.<\/jats:p>","DOI":"10.1042\/bst0370597","type":"journal-article","created":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T13:18:20Z","timestamp":1242825500000},"page":"597-604","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Understanding the functions of BRCA1 in the DNA-damage response"],"prefix":"10.1042","volume":"37","author":[{"given":"Maximina\u00a0H.","family":"Yun","sequence":"first","affiliation":[{"name":"Division of Protein and Nucleic Acids Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hiom","sequence":"additional","affiliation":[{"name":"Division of Protein and Nucleic Acids Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2009,5,20]]},"reference":[{"key":"2021111718531873100_B1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.1088759","article-title":"Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2","volume":"302","author":"King","year":"2003","journal-title":"Science"},{"key":"2021111718531873100_B2","first-page":"4978","article-title":"Haplo-insufficiency of BRCA1 in sporadic breast cancer","volume":"63","author":"Staff","year":"2003","journal-title":"Cancer Res."},{"key":"2021111718531873100_B3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(02)00615-3","article-title":"Cancer susceptibility and the functions of BRCA1 and BRCA2","volume":"108","author":"Venkitaraman","year":"2002","journal-title":"Cell"},{"key":"2021111718531873100_B4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/35044000","article-title":"In search of the tumour-suppressor functions of BRCA1 and BRCA2","volume":"408","author":"Scully","year":"2000","journal-title":"Nature"},{"key":"2021111718531873100_B5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1097-2765(00)80202-6","article-title":"Brca1 controls homology-directed DNA repair","volume":"4","author":"Moynahan","year":"1999","journal-title":"Mol. 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