{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:48:52Z","timestamp":1791254932069,"version":"4.1.0"},"reference-count":62,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:p>Anti-angiogenic VEGF (vascular endothelial growth factor) isoforms, generated from differential splicing of exon 8, are widely expressed in normal human tissues but down-regulated in cancers and other pathologies associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys\u2013Drash syndrome and pre-eclampsia). Administration of recombinant VEGF165b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma and metastatic melanoma. Splicing factors and their regulatory molecules alter splice site selection, such that cells can switch from the anti-angiogenic VEGFxxxb isoforms to the pro-angiogenic VEGFxxx isoforms, including SRp55 (serine\/arginine protein 55), ASF\/SF2 (alternative splicing factor\/splicing factor 2) and SRPK (serine arginine domain protein kinase), and inhibitors of these molecules can inhibit angiogenesis in the eye, and splice site selection in cancer cells, opening up the possibility of using splicing factor inhibitors as novel anti-angiogenic therapeutics. Endogenous anti-angiogenic VEGFxxxb isoforms are cytoprotective for endothelial, epithelial and neuronal cells in vitro and in vivo, suggesting both an improved safety profile and an explanation for unpredicted anti-VEGF side effects. In summary, C-terminal distal splicing is a key component of VEGF biology, overlooked by the vast majority of publications in the field, and these findings require a radical revision of our understanding of VEGF biology in normal human physiology.<\/jats:p>","DOI":"10.1042\/bst0371207","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T18:02:29Z","timestamp":1258653749000},"page":"1207-1213","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["The anti-angiogenic isoforms of VEGF in health and disease"],"prefix":"10.1042","volume":"37","author":[{"given":"Yan","family":"Qiu","sequence":"first","affiliation":[{"name":"Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Hoareau-Aveilla","sequence":"additional","affiliation":[{"name":"Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Oltean","sequence":"additional","affiliation":[{"name":"Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven\u00a0J.","family":"Harper","sequence":"additional","affiliation":[{"name":"Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0O.","family":"Bates","sequence":"additional","affiliation":[{"name":"Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2009,11,19]]},"reference":[{"key":"2021111719295133600_B1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat. Med."},{"key":"2021111719295133600_B2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2003-0027","article-title":"Vascular endothelial growth factor: basic science and clinical progress","volume":"25","author":"Ferrara","year":"2004","journal-title":"Endocr. Rev."},{"key":"2021111719295133600_B3","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1210\/endo.141.3.7369","article-title":"Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor","volume":"141","author":"Fraser","year":"2000","journal-title":"Endocrinology"},{"key":"2021111719295133600_B4","doi-asserted-by":"crossref","first-page":"8915","DOI":"10.1073\/pnas.90.19.8915","article-title":"Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth","volume":"90","author":"Peters","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111719295133600_B5","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","article-title":"Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer","volume":"350","author":"Hurwitz","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2021111719295133600_B6","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"2021111719295133600_B7","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"2021111719295133600_B8","first-page":"1673","article-title":"Vascular endothelial growth factor\/vascular permeability factor (VEGF\/VPF) in normal and atherosclerotic human arteries","volume":"150","author":"Couffinhal","year":"1997","journal-title":"Am. J. Pathol."},{"key":"2021111719295133600_B9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1471-0528.1996.tb09627.x","article-title":"VEGF mRNA levels in placentae from pregnancies complicated by pre-eclampsia","volume":"103","author":"Cooper","year":"1996","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"2021111719295133600_B10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1084\/jem.180.1.341","article-title":"Vascular permeability factor\/endothelial growth factor (VPF\/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue","volume":"180","author":"Fava","year":"1994","journal-title":"J. Exp. Med."},{"key":"2021111719295133600_B11","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1210\/mend-5-12-1806","article-title":"The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA","volume":"5","author":"Houck","year":"1991","journal-title":"Mol. Endocrinol."},{"key":"2021111719295133600_B12","first-page":"4123","article-title":"VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma","volume":"62","author":"Bates","year":"2002","journal-title":"Cancer Res."},{"key":"2021111719295133600_B13","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1007\/s00125-005-1951-8","article-title":"Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor","volume":"48","author":"Perrin","year":"2005","journal-title":"Diabetologia"},{"key":"2021111719295133600_B14","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1158\/0008-5472.CAN-04-0934","article-title":"VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression","volume":"64","author":"Woolard","year":"2004","journal-title":"Cancer Res."},{"key":"2021111719295133600_B15","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/sj.bjc.6605249","article-title":"VEGF121b, a new member of the VEGFxxxb family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo","volume":"101","author":"Rennel","year":"2009","journal-title":"Br. J. Cancer"},{"key":"2021111719295133600_B16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.biopha.2007.07.015","article-title":"5-Aza-2-deoxycytidine increases the expression of antiangiogenic vascular endothelial growth factor 189b variant in human lung microvascular endothelial cells","volume":"62","author":"Miller-Kasprzak","year":"2008","journal-title":"Biomed. Pharmacother."},{"key":"2021111719295133600_B17","first-page":"752","article-title":"Human M\u00fcller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor","volume":"40","author":"Jingjing","year":"1999","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"2021111719295133600_B18","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1083\/jcb.200703052","article-title":"Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents","volume":"179","author":"Mineur","year":"2007","journal-title":"J. Cell Biol."},{"key":"2021111719295133600_B19","doi-asserted-by":"crossref","first-page":"17164","DOI":"10.1074\/jbc.M212224200","article-title":"VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cells","volume":"278","author":"Lange","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021111719295133600_B20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1042\/CS19990016","article-title":"Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant","volume":"97","author":"Whittle","year":"1999","journal-title":"Clin. Sci."},{"key":"2021111719295133600_B21","doi-asserted-by":"crossref","first-page":"F767","DOI":"10.1152\/ajprenal.00337.2003","article-title":"Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and protein","volume":"286","author":"Cui","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2021111719295133600_B22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/mrd.20589","article-title":"Characterization and differential expression of vascular endothelial growth factor isoforms and receptors in swine corpus luteum throughout estrous cycle","volume":"74","author":"Ribeiro","year":"2007","journal-title":"Mol. Reprod. Dev."},{"key":"2021111719295133600_B23","first-page":"1517","article-title":"Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma","volume":"14","author":"Ergorul","year":"2008","journal-title":"Mol. Vision"},{"key":"2021111719295133600_B24","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1095\/biolreprod.109.078097","article-title":"Neutralization of vascular endothelial growth factor inhibitory isoforms is more effective than treatment with angiogenic isoforms in stimulating vascular development and follicle progression in the perinatal rat ovary","volume":"81","author":"Artac","year":"2009","journal-title":"Biol. Reprod."},{"key":"2021111719295133600_B25","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s00018-006-6254-9","article-title":"A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2","volume":"63","author":"Cebe\u00a0Suarez","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"2021111719295133600_B26","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.ejca.2008.05.027","article-title":"Recombinant human VEGF165b protein is an effective anti-cancer agent in mice","volume":"44","author":"Rennel","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"2021111719295133600_B27","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/sj.bjc.6604308","article-title":"VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy","volume":"98","author":"Varey","year":"2008","journal-title":"Br. J. Cancer"},{"key":"2021111719295133600_B28","first-page":"1","article-title":"Molecular diversity of VEGF-A as a regulator of its biological activity","volume":"10","author":"Woolard","year":"2009","journal-title":"Microcirculation"},{"key":"2021111719295133600_B29","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1096\/fj.07-9718com","article-title":"Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b","volume":"22","author":"Qiu","year":"2008","journal-title":"FASEB J."},{"key":"2021111719295133600_B30","doi-asserted-by":"crossref","first-page":"p57","DOI":"10.1159\/000177614","article-title":"The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development","volume":"110","author":"Bevan","year":"2008","journal-title":"Nephron Physiol."},{"key":"2021111719295133600_B31","first-page":"626","article-title":"VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice","volume":"12","author":"Konopatskaya","year":"2006","journal-title":"Mol. Vision"},{"key":"2021111719295133600_B32","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1042\/CS20050292","article-title":"The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term","volume":"110","author":"Bates","year":"2006","journal-title":"Clin. Sci."},{"key":"2021111719295133600_B33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/000456329703400309","article-title":"Variation in detection of VEGF in maternal serum by immunoassay and the possible influence of binding proteins","volume":"34","author":"Anthony","year":"1997","journal-title":"Ann. Clin. Biochem."},{"key":"2021111719295133600_B34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2021111719295133600_B35","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.ajog.2004.03.004","article-title":"Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop","volume":"191","author":"McKeeman","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021111719295133600_B36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/sj.bjc.6603839","article-title":"Expression of VEGFxxxb, the inhibitory isoforms of VEGF, in malignant melanoma","volume":"97","author":"Pritchard-Jones","year":"2007","journal-title":"Br. J. Cancer"},{"key":"2021111719295133600_B37","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1681\/ASN.2006020124","article-title":"Impaired glomerular maturation and lack of VEGF165b in Denys\u2013Drash syndrome","volume":"18","author":"Schumacher","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021111719295133600_B38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1095\/biolreprod.105.047225","article-title":"Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat","volume":"75","author":"Bott","year":"2006","journal-title":"Biol. Reprod."},{"key":"2021111719295133600_B39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/09513599709152564","article-title":"Expression of vascular endothelial growth factor (VEGF) during folliculogenesis and corpus luteum formation in the human ovary","volume":"11","author":"Yamamoto","year":"1997","journal-title":"Gynecol. Endocrinol."},{"key":"2021111719295133600_B40","first-page":"157","article-title":"Expression of vascular permeability factor\/vascular endothelial growth factor by human granulosa and theca lutein cells: role in corpus luteum development","volume":"146","author":"Kamat","year":"1995","journal-title":"Am. J. Pathol."},{"key":"2021111719295133600_B41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/08977199409011000","article-title":"Immunolocalisation of vascular endothelial growth factor in human endometrium","volume":"11","author":"Li","year":"1994","journal-title":"Growth Factors"},{"key":"2021111719295133600_B42","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1095\/biolreprod56.6.1390","article-title":"Expression of vascular endothelial growth factor (VEGF) and VEGF-receptor messenger ribonucleic acids in the peri-implantation rabbit uterus","volume":"56","author":"Das","year":"1997","journal-title":"Biol. Reprod."},{"key":"2021111719295133600_B43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"key":"2021111719295133600_B44","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/1097-0177(200007)218:3<507::AID-DVDY1012>3.0.CO;2-5","article-title":"Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution","volume":"218","author":"Pepper","year":"2000","journal-title":"Dev. Dyn."},{"key":"2021111719295133600_B44a","first-page":"452","article-title":"VEGF165b overexpression inhibits ovarian follicle development","volume":"16","author":"Qiu","year":"2009","journal-title":"Microcirculation"},{"key":"2021111719295133600_B44b","doi-asserted-by":"crossref","first-page":"592.17","DOI":"10.1096\/fasebj.23.1_supplement.592.17","article-title":"Overexpression of VEGF165b in mouse ovary results in reduced litter size","volume":"23","author":"Qiu","year":"2009","journal-title":"FASEB J."},{"key":"2021111719295133600_B45","first-page":"18","article-title":"Regulation of vascular endothelial growth factor (VEGFA) isoforms may be a mechanism to regulate sex-specific vascular development, cord formation and follicle progression within developing gonads","volume":"45","author":"Cupp","year":"2008","journal-title":"J. Vasc. Res."},{"key":"2021111719295133600_B46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20080270","article-title":"Failure to up-regulate VEGF165b in maternal plasma is at first trimester predictive marker for pre-eclampsia","volume":"116","author":"Bills","year":"2009","journal-title":"Clin. Sci."},{"key":"2021111719295133600_B47","first-page":"117","article-title":"Insulin perfusion decreases expression of the splice variant VEGF165b in large vessels of the human term chorionic stem villi but not in microvessels","volume":"45","author":"Sciota","year":"2008","journal-title":"J. Vasc. Res."},{"key":"2021111719295133600_B48","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1172\/JCI17423","article-title":"Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases","volume":"111","author":"Eremina","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2021111719295133600_B49","first-page":"643","article-title":"Ultrafiltration co-efficient in isolated intact glomeruli from podocyte-specific VEGF165b over-expressing transgenic mice","volume":"14","author":"Ferguson","year":"2007","journal-title":"Microcirculation"},{"key":"2021111719295133600_B50","article-title":"Over-expression of VEGF165b in the kidney ameliorates diabetes induced albuminuria","volume-title":"Renal Association Annual Congress, 21\u201324 April 2009","author":"Ferguson","year":"2009"},{"key":"2021111719295133600_B51","article-title":"The effect of exogenous VEGF165b on the normalised ultrafiltration coefficient in isolated intact mice glomeruli","volume-title":"Renal Association Annual Congress, 21\u201324 April 2009","author":"Kaura","year":"2009"},{"key":"2021111719295133600_B52","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/sj.bjc.6604309","article-title":"The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice","volume":"98","author":"Rennel","year":"2008","journal-title":"Br. J. Cancer"},{"key":"2021111719295133600_B52a","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/157339909787314149","article-title":"Diabetic retinopathy and angiogenesis","volume":"5","author":"Crawford","year":"2009","journal-title":"Curr. Diabetes Rev."},{"key":"2021111719295133600_B52b","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/ICU.0b013e32832d25b3","article-title":"Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration","volume":"20","author":"Ciulla","year":"2009","journal-title":"Curr. Opin. Ophthalmol."},{"key":"2021111719295133600_B53","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1158\/0008-5472.CAN-07-6577","article-title":"Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity","volume":"68","author":"Kawamura","year":"2008","journal-title":"Cancer Res."},{"key":"2021111719295133600_B54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1113\/jphysiol.2005.103127","article-title":"The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo","volume":"572","author":"Glass","year":"2006","journal-title":"J. Physiol."},{"key":"2021111719295133600_B55","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1242\/jcs.016410","article-title":"Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors","volume":"121","author":"Nowak","year":"2008","journal-title":"J. Cell Sci."},{"key":"2021111719295133600_B55a","article-title":"Regulation of VEGF splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis","author":"Nowak","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021111719295133600_B56","doi-asserted-by":"crossref","first-page":"15042","DOI":"10.1073\/pnas.0507827102","article-title":"Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2\/alternative splicing factor","volume":"102","author":"Sanford","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111719295133600_B57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nsmb1209","article-title":"The gene encoding the splicing factor SF2\/ASF is a proto- oncogene","volume":"14","author":"Karni","year":"2007","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/37\/6\/1207\/546680\/bst0371207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/37\/6\/1207\/546680\/bst0371207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T21:40:45Z","timestamp":1637185245000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/37\/6\/1207\/64901\/The-anti-angiogenic-isoforms-of-VEGF-in-health-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,19]]},"references-count":62,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,11,19]]},"published-print":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bst0371207","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,19]]}}}