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Lamins affect the activity of several transcription factors, such as retinoblastoma protein and c-Fos, and signalling pathways, such as the ERK1\/2 (extracellular-signal-regulated kinase 1\/2) and Notch pathways, which are key regulators of cell-cycle progression and differentiation. During mitosis, lamins are dynamically reorganized and play active roles in spindle matrix formation and in post-mitotic nuclear reassembly. Several of the cell-cycle-regulating functions of lamins may be impaired in the diseases linked to mutations in lamins and lamin-associated proteins, including striated muscle diseases, lipodystrophies and premature aging syndromes, and contribute to the tissue-specific disease pathologies.<\/jats:p>","DOI":"10.1042\/bst0380301","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T16:17:54Z","timestamp":1264004274000},"page":"301-306","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Lamins: \u2018structure goes cycling\u2019"],"prefix":"10.1042","volume":"38","author":[{"given":"Mirta","family":"Boban","sequence":"first","affiliation":[{"name":"Max F. 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