{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:00:38Z","timestamp":1791165638320,"version":"4.1.0"},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:p>Genistein [4\u2032,5,7-trihydroxyisoflavone or 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one] is a natural isoflavone occurring in many plants known to possess various biological activities, ranging from phyto-oestrogenic to antioxidative actions. Recent studies indicated that this isoflavone can also be considered as a drug for as yet untreatable genetic diseases. In the present review, we discuss a plausible use of genistein in treatment of two genetic disorders: CF (cystic fibrosis) and MPS (mucopolysaccharidosis). Although various biological actions of genistein are employed in these two cases, in vitro studies, tests on animal models and pilot clinical trials suggest that this plant-derived compound might be a real hope for patients suffering from severe inherited disorders with relatively complicated pathomechanisms, including those affecting the central nervous system.<\/jats:p>","DOI":"10.1042\/bst0380695","type":"journal-article","created":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T14:16:27Z","timestamp":1269440187000},"page":"695-701","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Genistein: a natural isoflavone with a potential for treatment of genetic diseases"],"prefix":"10.1042","volume":"38","author":[{"given":"Grzegorz","family":"W\u0119grzyn","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Jak\u00f3bkiewicz-Banecka","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Gabig-Cimi\u0144ska","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology (affiliated with the University of Gda\u0144sk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Piotrowska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Narajczyk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kloska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelina","family":"Malinowska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Go\u0142\u0119biewska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Moskot","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Gda\u0144sk, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"W\u0119grzyn","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology (affiliated with the University of Gda\u0144sk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, K\u0142adki 24, 80-822 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2010,3,22]]},"reference":[{"key":"2021111720545306800_B1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-9422(02)00116-4","article-title":"Genistein","volume":"60","author":"Dixon","year":"2002","journal-title":"Phytochemistry"},{"key":"2021111720545306800_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01635580701267677","article-title":"Review on the factors affecting bioavailability of soy isoflavones in humans","volume":"57","author":"Nielsen","year":"2007","journal-title":"Nutr. 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