{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:38:19Z","timestamp":1791319099896,"version":"4.3.1"},"reference-count":274,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:p>In addition to their normal physiological role in ATP production and metabolism, mitochondria exhibit a dark side mediated by the opening of a non-specific pore in the inner mitochondrial membrane. This mitochondrial permeability transition pore (MPTP) causes the mitochondria to breakdown rather than synthesize ATP and, if unrestrained, leads to necrotic cell death. The MPTP is opened in response to Ca2+ overload, especially when accompanied by oxidative stress, elevated phosphate concentration and adenine nucleotide depletion. These conditions are experienced by the heart and brain subjected to reperfusion after a period of ischaemia as may occur during treatment of a myocardial infarction or stroke and during heart surgery. In the present article, I review the properties, regulation and molecular composition of the MPTP. The evidence for the roles of CyP-D (cyclophilin D), the adenine nucleotide translocase and the phosphate carrier are summarized and other potential interactions with outer mitochondrial membrane proteins are discussed. I then review the evidence that MPTP opening mediates cardiac reperfusion injury and that MPTP inhibition is cardioprotective. Inhibition may involve direct pharmacological targeting of the MPTP, such as with cyclosporin A that binds to CyP-D, or indirect inhibition of MPTP opening such as with preconditioning protocols. These invoke complex signalling pathways to reduce oxidative stress and Ca2+ load. MPTP inhibition also protects against congestive heart failure in hypertensive animal models. Thus the MPTP is a very promising pharmacological target for clinical practice, especially once more specific drugs are developed.<\/jats:p>","DOI":"10.1042\/bst0380841","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T09:48:48Z","timestamp":1280224128000},"page":"841-860","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":278,"title":["A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection"],"prefix":"10.1042","volume":"38","author":[{"given":"Andrew\u00a0P.","family":"Halestrap","sequence":"first","affiliation":[{"name":"1Department of Biochemistry and The Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2010,7,26]]},"reference":[{"key":"2021111720074591700_B1","doi-asserted-by":"crossref","first-page":"16455","DOI":"10.1074\/jbc.X200011200","article-title":"Keilin, cytochrome, and the respiratory chain","volume":"278","author":"Slater","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0092-8674(00)80442-0","article-title":"Cytochrome c: can't live with it \u2013 can't live without it","volume":"91","author":"Reed","year":"1997","journal-title":"Cell"},{"key":"2021111720074591700_B3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","article-title":"Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"2021111720074591700_B4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1042\/bst0280170","article-title":"Mitochondria and cell death","volume":"28","author":"Halestrap","year":"2000","journal-title":"Biochem. Soc. 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Cell Biol."},{"key":"2021111720074591700_B11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.molcel.2006.04.014","article-title":"A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death","volume":"22","author":"Reef","year":"2006","journal-title":"Mol. Cell"},{"key":"2021111720074591700_B12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0021-9258(19)50798-0","article-title":"The effect of thyroxine and other substances on the swelling of isolated rat liver mitochondria","volume":"222","author":"Tapley","year":"1956","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0021-9258(19)52312-2","article-title":"Inactivation of oxidative and phosphorylative systems in mitochondria by preincubation with phosphate and other ions","volume":"216","author":"Hunter","year":"1955","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1042\/bj0950378","article-title":"Calcium ion accumulation and volume changes of isolated liver mitochondria","volume":"95","author":"Chappell","year":"1965","journal-title":"Biochem. J."},{"key":"2021111720074591700_B15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bj2680153","article-title":"Inhibition of Ca2+-induced large amplitude swelling of liver and heart mitochondria by cyclosporin A is probably caused by the inhibitor binding to mitochondrial matrix peptidyl-prolyl cis\u2013trans isomerase and preventing it interacting with the adenine nucleotide translocase","volume":"268","author":"Halestrap","year":"1990","journal-title":"Biochem. J."},{"key":"2021111720074591700_B16","doi-asserted-by":"crossref","first-page":"C755","DOI":"10.1152\/ajpcell.1990.258.5.C755","article-title":"Mechanisms by which mitochondria transport calcium","volume":"258","author":"Gunter","year":"1990","journal-title":"Am. J. Physiol."},{"key":"2021111720074591700_B17","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0003-9861(79)90372-2","article-title":"The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site","volume":"195","author":"Haworth","year":"1979","journal-title":"Arch. Biochem. Biophys."},{"key":"2021111720074591700_B18","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1016\/S0021-9258(17)33220-9","article-title":"Relationship between configuration, function and permeability in calcium-treated mitochondria","volume":"251","author":"Hunter","year":"1976","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0003-9861(79)90371-0","article-title":"The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms","volume":"195","author":"Hunter","year":"1979","journal-title":"Arch. Biochem. Biophys."},{"key":"2021111720074591700_B20","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/0003-9861(79)90373-4","article-title":"The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ release","volume":"195","author":"Hunter","year":"1979","journal-title":"Arch. Biochem. Biophys."},{"key":"2021111720074591700_B21","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1042\/bj2450915","article-title":"Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria","volume":"245","author":"Crompton","year":"1987","journal-title":"Biochem. J."},{"key":"2021111720074591700_B22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1432-1033.1988.tb14475.x","article-title":"Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress: a potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload","volume":"178","author":"Crompton","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"2021111720074591700_B23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/bj2390019","article-title":"The reversible Ca2+-induced permeabilisation of rat liver mitochondria","volume":"239","author":"Al-Nasser","year":"1986","journal-title":"Biochem. J."},{"key":"2021111720074591700_B24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/bss0660181","article-title":"The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury","volume":"66","author":"Halestrap","year":"1999","journal-title":"Biochem. Soc. Symp."},{"key":"2021111720074591700_B25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death","volume":"341","author":"Crompton","year":"1999","journal-title":"Biochem. J."},{"key":"2021111720074591700_B26","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1042\/bj0950378","article-title":"Calcium ion accumulation and volume changes of isolated liver mitochondria: calcium ion-induced swelling","volume":"95","author":"Chappell","year":"1965","journal-title":"Biochem. J."},{"key":"2021111720074591700_B27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1042\/bj2660033","article-title":"A heart mitochondrial Ca2+-dependent pore of possible relevance to re-perfusion-induced injury: evidence that ADP facilitates pore interconversion between the closed and open states","volume":"266","author":"Crompton","year":"1990","journal-title":"Biochem. J."},{"key":"2021111720074591700_B28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0005-2728(89)80378-0","article-title":"The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro, and its role in the control of mitochondrial metabolism","volume":"973","author":"Halestrap","year":"1989","journal-title":"Biochim. Biophys. 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J."},{"key":"2021111720074591700_B32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bj2460715","article-title":"Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content","volume":"246","author":"Davidson","year":"1987","journal-title":"Biochem. J."},{"key":"2021111720074591700_B33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/bj2540379","article-title":"Inorganic pyrophosphate is located primarily in the mitochondria of the hepatocyte and increases in parallel with the decrease in light-scattering induced by gluconeogenic hormones, butyrate and ionophore A23187","volume":"254","author":"Davidson","year":"1988","journal-title":"Biochem. J."},{"key":"2021111720074591700_B34","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1042\/bj2580817","article-title":"Inhibition of mitochondrial matrix inorganic pyrophosphatase by physiological [Ca2+], and its role in the hormonal regulation of mitochondrial matrix volume","volume":"258","author":"Davidson","year":"1989","journal-title":"Biochem. J."},{"key":"2021111720074591700_B35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0014-5793(71)80363-0","article-title":"Opposite effects of bongkrekic acid and atractyloside on the adenine nucleotides induced mitochondrial volume changes and on the efflux of adenine nucleotides","volume":"16","author":"Klingenberg","year":"1971","journal-title":"FEBS Lett."},{"key":"2021111720074591700_B36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.56.1.65","article-title":"Adenine nucleotide-induced contraction on the inner mitochondrial membrane. II. Effect of bongkrekic acid","volume":"56","author":"Stoner","year":"1973","journal-title":"J. Cell. Biol."},{"key":"2021111720074591700_B37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1083\/jcb.56.1.51","article-title":"Adenine nucleotide-induced contraction of the inner mitochondrial membrane. I. General characterization","volume":"56","author":"Stoner","year":"1973","journal-title":"J. Cell. Biol."},{"key":"2021111720074591700_B38","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0003-9861(80)90298-2","article-title":"Adenine nucleotide translocase as a site of regulation by ADP of the rat liver mitochondrial permeability to H+ and K+ ions","volume":"199","author":"Panov","year":"1980","journal-title":"Arch. Biochem. Biophys."},{"key":"2021111720074591700_B39","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1074360","article-title":"Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane","volume":"298","author":"Xu","year":"2002","journal-title":"Science"},{"key":"2021111720074591700_B40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.physiol.69.031905.163804","article-title":"Mitochondrial ion channels","volume":"69","author":"O'Rourke","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"2021111720074591700_B41","first-page":"357","article-title":"Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress","volume":"255","author":"Crompton","year":"1988","journal-title":"Biochem. J."},{"key":"2021111720074591700_B42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0300-9084(02)01368-8","article-title":"Mitochondrial intermembrane junctional complexes and their involvement in cell death","volume":"84","author":"Crompton","year":"2002","journal-title":"Biochimie"},{"key":"2021111720074591700_B43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/9780470725207.ch11","article-title":"The mitochondrial permeability transition pore","volume":"287","author":"Bernardi","year":"2007","journal-title":"Novartis Found. Symp."},{"key":"2021111720074591700_B44","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2009.02.021","article-title":"What is the mitochondrial permeability transition pore?","volume":"46","author":"Halestrap","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021111720074591700_B45","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1016\/S0021-9258(19)67802-6","article-title":"The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin-A","volume":"266","author":"Szabo","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B46","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF00762739","article-title":"Electrophysiology of the inner mitochondrial membrane","volume":"26","author":"Zoratti","year":"1994","journal-title":"J. Bioenerg. Biomembr."},{"key":"2021111720074591700_B47","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1074\/jbc.271.9.4846","article-title":"Activity of the mitochondrial multiple conductance channel is independent of the adenine nucleotide translocator","volume":"271","author":"Lohret","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0005-2728(98)00119-4","article-title":"From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore: switching from low- to high-conductance state","volume":"1366","author":"Ichas","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111720074591700_B49","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0092-8674(00)80301-3","article-title":"Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals","volume":"89","author":"Ichas","year":"1997","journal-title":"Cell"},{"key":"2021111720074591700_B50","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.1999.79.4.1127","article-title":"Mitochondrial transport of cations: channels, exchangers, and permeability transition","volume":"79","author":"Bernardi","year":"1999","journal-title":"Physiol. Rev."},{"key":"2021111720074591700_B51","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.1016\/S0021-9258(19)50355-6","article-title":"Modulation of the mitochondrial cyclosporin-A-sensitive permeability transition pore by the proton electrochemical gradient: evidence that the pore can be opened by membrane depolarization","volume":"267","author":"Bernardi","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B52","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1432-1327.1999.00725.x","article-title":"Mitochondria and cell death: mechanistic aspects and methodological issues","volume":"264","author":"Bernardi","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"2021111720074591700_B53","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0006-3495(99)77239-5","article-title":"Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence","volume":"76","author":"Petronilli","year":"1999","journal-title":"Biophys. J."},{"key":"2021111720074591700_B54","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0021-9258(18)54034-5","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. 2. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+","volume":"268","author":"Petronilli","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B55","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1016\/S0021-9258(19)50676-7","article-title":"Modulation of the mitochondrial permeability transition pore: effect of protons and divalent cations","volume":"267","author":"Bernardi","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/abbi.1994.1230","article-title":"Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP","volume":"311","author":"Novgorodov","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"2021111720074591700_B57","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bj2780715","article-title":"Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7: implications for the protective effect of low pH against chemical and hypoxic cell damage","volume":"278","author":"Halestrap","year":"1991","journal-title":"Biochem. J."},{"key":"2021111720074591700_B58","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1016\/S0021-9258(19)50677-9","article-title":"Modulation of the mitochondrial megachannel by divalent cations and protons","volume":"267","author":"Szabo","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B59","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0021-9258(18)54033-3","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. 1. 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Chem."},{"key":"2021111720074591700_B62","doi-asserted-by":"crossref","first-page":"26312","DOI":"10.1074\/jbc.M805235200","article-title":"The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition","volume":"283","author":"Leung","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B63","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.yjmcc.2009.03.006","article-title":"A CaPful of mechanisms regulating the mitochondrial permeability transition","volume":"46","author":"Di\u00a0Lisa","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021111720074591700_B64","doi-asserted-by":"crossref","first-page":"H2024","DOI":"10.1152\/ajpheart.00683.2005","article-title":"Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia\u2013reperfusion","volume":"290","author":"Kim","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021111720074591700_B65","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1196\/annals.1420.023","article-title":"The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown","volume":"1123","author":"Juhaszova","year":"2008","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2021111720074591700_B66","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1054\/ceca.2000.0168","article-title":"Mitochondrial calcium transport: mechanisms and functions","volume":"28","author":"Gunter","year":"2000","journal-title":"Cell Calcium"},{"key":"2021111720074591700_B67","doi-asserted-by":"crossref","first-page":"12295","DOI":"10.1074\/jbc.272.19.12295","article-title":"On the voltage dependence of the mitochondrial permeability transition pore: a critical appraisal","volume":"272","author":"Scorrano","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B68","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0167-5699(92)90111-J","article-title":"The mechanism of action of cyclosporin-A and FK506","volume":"13","author":"Schreiber","year":"1992","journal-title":"Immunol. 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J."},{"key":"2021111720074591700_B71","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0167-4781(97)00017-1","article-title":"cDNA cloning of rat mitochondrial cyclophilin","volume":"1351","author":"Woodfield","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111720074591700_B72","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1432-1327.1999.00490.x","article-title":"Import and processing of heart mitochondrial cyclophilin D","volume":"263","author":"Johnson","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"2021111720074591700_B73","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1124\/mol.62.1.22","article-title":"Inhibition of the mitochondrial permeability transition by the non-immunosuppressive cyclosporin derivative NIM811","volume":"62","author":"Waldmeier","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"2021111720074591700_B74","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1023\/B:JOBB.0000041776.31885.45","article-title":"The non-immunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria","volume":"36","author":"Hansson","year":"2004","journal-title":"J. Bioenerg. Biomembr."},{"key":"2021111720074591700_B75","doi-asserted-by":"crossref","first-page":"H1654","DOI":"10.1152\/ajpheart.01378.2006","article-title":"Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice","volume":"293","author":"Gomez","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021111720074591700_B76","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/BJ20090332","article-title":"Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation","volume":"425","author":"Malouitre","year":"2010","journal-title":"Biochem. J."},{"key":"2021111720074591700_B77","doi-asserted-by":"crossref","first-page":"18558","DOI":"10.1074\/jbc.C500089200","article-title":"Properties of the permeability transition pore in mitochondria devoid of cyclophilin D","volume":"280","author":"Basso","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B78","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/434578a","article-title":"A pore way to die","volume":"434","author":"Halestrap","year":"2005","journal-title":"Nature"},{"key":"2021111720074591700_B79","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"2021111720074591700_B80","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"2021111720074591700_B81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(01)03314-2","article-title":"Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?","volume":"512","author":"He","year":"2002","journal-title":"FEBS Lett."},{"key":"2021111720074591700_B82","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2174\/0929867033457278","article-title":"The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death","volume":"10","author":"Halestrap","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"2021111720074591700_B83","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj3360287","article-title":"Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition","volume":"336","author":"Woodfield","year":"1998","journal-title":"Biochem. J."},{"key":"2021111720074591700_B84","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1046\/j.1432-1327.1998.2580729.x","article-title":"Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore","volume":"258","author":"Crompton","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"2021111720074591700_B85","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/bj20011672","article-title":"Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore","volume":"367","author":"McStay","year":"2002","journal-title":"Biochem. J."},{"key":"2021111720074591700_B86","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj2440159","article-title":"The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in matrix volume induced by osmotic strength, valinomycin and Ca2+","volume":"244","author":"Halestrap","year":"1987","journal-title":"Biochem. J."},{"key":"2021111720074591700_B87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature02056","article-title":"Structure of mitochondrial ADP\/ATP carrier in complex with carboxyatractyloside","volume":"426","author":"Pebay-Peyroula","year":"2003","journal-title":"Nature"},{"key":"2021111720074591700_B88","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1021\/bi960833v","article-title":"Mitochondrial ADP\/ATP carrier can be reversibly converted into a large channel by Ca2+","volume":"35","author":"Brustovetsky","year":"1996","journal-title":"Biochemistry"},{"key":"2021111720074591700_B89","doi-asserted-by":"crossref","first-page":"11804","DOI":"10.1021\/bi0200110","article-title":"A large Ca2+-dependent channel formed by recombinant ADP\/ATP carrier from Neurospora crassa resembles the mitochondrial permeability transition pore","volume":"41","author":"Brustovetsky","year":"2002","journal-title":"Biochemistry"},{"key":"2021111720074591700_B90","doi-asserted-by":"crossref","first-page":"21104","DOI":"10.1074\/jbc.272.34.21104","article-title":"Properties of a cyclosporin-insensitive permeability transition pore in yeast mitochondria","volume":"272","author":"Jung","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B91","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1023\/A:1020533928491","article-title":"Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore?","volume":"30","author":"Manon","year":"1998","journal-title":"J. Bioenerg. Biomembr."},{"key":"2021111720074591700_B92","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.bbabio.2009.07.001","article-title":"Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions","volume":"1787","author":"Yamada","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111720074591700_B93","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1016\/j.febslet.2010.04.023","article-title":"The mitochondrial permeability transition from yeast to mammals","volume":"584","author":"Azzolin","year":"2010","journal-title":"FEBS Lett."},{"key":"2021111720074591700_B94","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02229","article-title":"The ADP\/ATP translocator is not essential for the mitochondrial permeability transition pore","volume":"427","author":"Kokoszka","year":"2004","journal-title":"Nature"},{"key":"2021111720074591700_B95","doi-asserted-by":"crossref","first-page":"41566","DOI":"10.1074\/jbc.M304940200","article-title":"Proteomic analysis of the mouse liver mitochondrial inner membrane","volume":"278","author":"Da\u00a0Cruz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B96","doi-asserted-by":"crossref","DOI":"10.1038\/nature02816","article-title":"Dual role for the ADP\/ATP translocator?","volume":"430","author":"Halestrap","year":"2004","journal-title":"Nature"},{"key":"2021111720074591700_B97","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.bbabio.2008.03.009","article-title":"Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore","volume":"1777","author":"Leung","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111720074591700_B98","doi-asserted-by":"crossref","first-page":"19062","DOI":"10.1074\/jbc.M212661200","article-title":"The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria","volume":"278","author":"Chalmers","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B99","doi-asserted-by":"crossref","first-page":"26307","DOI":"10.1074\/jbc.C800132200","article-title":"Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation","volume":"283","author":"Basso","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B100","doi-asserted-by":"crossref","first-page":"25734","DOI":"10.1074\/jbc.273.40.25734","article-title":"A ubiquinone-binding site regulates the mitochondrial permeability transition pore","volume":"273","author":"Fontaine","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B101","doi-asserted-by":"crossref","first-page":"29521","DOI":"10.1074\/jbc.M004128200","article-title":"Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site","volume":"275","author":"Walter","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B102","doi-asserted-by":"crossref","first-page":"49812","DOI":"10.1074\/jbc.M304748200","article-title":"The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore","volume":"278","author":"Cesura","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B103","first-page":"590","article-title":"Biochim","volume":"1757","author":"Krauskopf","year":"2006","journal-title":"Biophys. Acta"},{"key":"2021111720074591700_B104","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/sj.onc.1210600","article-title":"A high-throughput screening for mammalian cell death effectors identifies the mitochondrial phosphate carrier as a regulator of cytochrome c release","volume":"27","author":"Alcala","year":"2008","journal-title":"Oncogene"},{"key":"2021111720074591700_B105","first-page":"2459","article-title":"Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine","volume":"61","author":"Tafani","year":"2001","journal-title":"Cancer Res."},{"key":"2021111720074591700_B106","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1073\/pnas.89.8.3170","article-title":"Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier","volume":"89","author":"Mcenery","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720074591700_B107","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1469-7793.2000.00011.x","article-title":"Mitochondrial intermembrane junctional complexes and their role in cell death","volume":"529","author":"Crompton","year":"2000","journal-title":"J. Physiol."},{"key":"2021111720074591700_B108","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ncb1575","article-title":"Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death","volume":"9","author":"Baines","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2021111720074591700_B109","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejphar.2006.12.027","article-title":"Peripheral benzodiazepine receptor ligand, PK11195 induces mitochondria cytochrome c release and dissipation of mitochondria potential via induction of mitochondria permeability transition","volume":"560","author":"Li","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"2021111720074591700_B110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0006-2952(00)00588-8","article-title":"Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue","volume":"61","author":"Chelli","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"2021111720074591700_B111","doi-asserted-by":"crossref","first-page":"31041","DOI":"10.1016\/S0021-9258(18)47387-5","article-title":"Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone","volume":"269","author":"Pastorino","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B112","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1124\/jpet.107.124255","article-title":"Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization","volume":"323","author":"Obame","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021111720074591700_B113","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ceca.2006.11.004","article-title":"The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria","volume":"42","author":"Azarashvili","year":"2007","journal-title":"Cell Calcium"},{"key":"2021111720074591700_B114","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1124\/jpet.110.167486","article-title":"TRO40303 (3,5-seco-4-nor-cholestan-5-one oxime-3-ol), a new cardioprotective compound inhibits mitochondrial permeability transition","volume":"333","author":"Schaller","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021111720074591700_B115","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.onc.1203298","article-title":"Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator","volume":"19","author":"Brenner","year":"2000","journal-title":"Oncogene"},{"key":"2021111720074591700_B116","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.187.8.1261","article-title":"The permeability transition pore complex: a target for apoptosis regulation by caspases and Bcl-2-related proteins","volume":"187","author":"Marzo","year":"1998","journal-title":"J. Exp. Med."},{"key":"2021111720074591700_B117","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-9084(02)01375-5","article-title":"The permeability transition pore complex: another view","volume":"84","author":"Halestrap","year":"2002","journal-title":"Biochimie"},{"key":"2021111720074591700_B118","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2174\/0929867033457197","article-title":"On the involvement of mitochondrial intermembrane junctional complexes in apoptosis","volume":"10","author":"Crompton","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"2021111720074591700_B119","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion: a target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B120","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1742-4658.2006.05213.x","article-title":"The mitochondrial permeability transition from in vitro artifact to disease target","volume":"273","author":"Bernardi","year":"2006","journal-title":"FEBS J."},{"key":"2021111720074591700_B121","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/35048069","article-title":"Breaking the mitochondrial barrier","volume":"2","author":"Martinou","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021111720074591700_B122","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"key":"2021111720074591700_B123","doi-asserted-by":"crossref","first-page":"10545","DOI":"10.1158\/0008-5472.CAN-05-1925","article-title":"Activation of glycogen synthase kinase 3\u03b2 disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity","volume":"65","author":"Pastorino","year":"2005","journal-title":"Cancer Res."},{"key":"2021111720074591700_B124","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1074\/jbc.M803614200","article-title":"Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity","volume":"284","author":"Arzoine","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B125","doi-asserted-by":"crossref","first-page":"12305","DOI":"10.1074\/jbc.C200703200","article-title":"Mitochondrial ATP synthasome: cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP\/ATP","volume":"278","author":"Ko","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B126","doi-asserted-by":"crossref","first-page":"31761","DOI":"10.1074\/jbc.M401353200","article-title":"Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP\/ATP","volume":"279","author":"Chen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B127","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/bj3070093","article-title":"Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion","volume":"307","author":"Griffiths","year":"1995","journal-title":"Biochem. J."},{"key":"2021111720074591700_B128","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00424-003-1099-7","article-title":"The mitochondrial transporter family (SLC25): physiological and pathological implications","volume":"447","author":"Palmieri","year":"2004","journal-title":"Pfl\u00fcgers Arch."},{"key":"2021111720074591700_B129","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1073\/pnas.0509994103","article-title":"Mitochondrial carriers in the cytoplasmic state have a common substrate binding site","volume":"103","author":"Robinson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720074591700_B130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0005-2728(98)00122-4","article-title":"Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart","volume":"1366","author":"Halestrap","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111720074591700_B131","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.bbabio.2008.12.017","article-title":"The role of the mitochondrial permeability transition pore in heart disease","volume":"1787","author":"Halestrap","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111720074591700_B132","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.me.42.020191.001301","article-title":"The cell biology of acute myocardial ischemia","volume":"42","author":"Jennings","year":"1991","journal-title":"Annu. Rev. Med."},{"key":"2021111720074591700_B133","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1540-8191.1993.tb01332.x","article-title":"Myocardial stunning and reperfusion injury in cardiac surgery","volume":"8","author":"Appleyard","year":"1993","journal-title":"J. Card. Surg."},{"key":"2021111720074591700_B134","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/physrev.1999.79.2.609","article-title":"Molecular and cellular mechanisms of myocardial stunning","volume":"79","author":"Bolli","year":"1999","journal-title":"Physiol. Rev."},{"key":"2021111720074591700_B135","doi-asserted-by":"crossref","first-page":"S644","DOI":"10.1016\/S0003-4975(02)04686-6","article-title":"Cellular mechanisms of ischemia\u2013reperfusion injury","volume":"75","author":"Piper","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"2021111720074591700_B136","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00059-008-3101-9","article-title":"Pathophysiology of myocardial infarction: protection by ischaemic pre- and postconditioning","volume":"33","author":"Skyschally","year":"2008","journal-title":"Herz"},{"key":"2021111720074591700_B137","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0163-7258(00)00102-9","article-title":"Mitochondria: a target for myocardial protection","volume":"89","author":"Suleiman","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"2021111720074591700_B138","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/cvr\/27.10.1790","article-title":"On the involvement of a cyclosporin-A sensitive mitochondrial pore in myocardial reperfusion injury","volume":"27","author":"Duchen","year":"1993","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B139","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1023\/A:1006827601337","article-title":"The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury","volume":"174","author":"Lemasters","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"2021111720074591700_B140","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0076-6879(99)02031-5","article-title":"Confocal imaging of Ca2+, pH, electrical potential, and membrane permeability in single living cells","volume":"302","author":"Lemasters","year":"1999","journal-title":"Methods Enzymol."},{"key":"2021111720074591700_B141","first-page":"P109","article-title":"A role of the mitochondrial permeability transition pore in cell injury by reactive oxygen species in isolated rat cardiomyocytes","volume":"494","author":"Leyssens","year":"1996","journal-title":"J. Physiol."},{"key":"2021111720074591700_B142"},{"key":"2021111720074591700_B143","doi-asserted-by":"crossref","first-page":"G823","DOI":"10.1152\/ajpgi.90287.2008","article-title":"Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia\u2013reperfusion","volume":"295","author":"Zhong","year":"2008","journal-title":"Am. J. Physiol. Gastroinstest. Liver Physiol."},{"key":"2021111720074591700_B144","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1124\/jpet.108.143578","article-title":"NIM811 (N-methyl-4isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice","volume":"327","author":"Rehman","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021111720074591700_B145","doi-asserted-by":"crossref","first-page":"36109","DOI":"10.1074\/jbc.M109.055301","article-title":"Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B146","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/cvr\/cvp094","article-title":"The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging","volume":"83","author":"Kato","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B147","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1006879618176","article-title":"Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia\/reperfusion injury","volume":"174","author":"Halestrap","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"2021111720074591700_B148","first-page":"H496","article-title":"Reversal of permeability transition during recovery of hearts from ischemia and its enhancement by pyruvate","volume":"276","author":"Kerr","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2021111720074591700_B149","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1074\/jbc.M006825200","article-title":"Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart","volume":"276","author":"DiLisa","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B150","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0022-2828(91)90181-K","article-title":"Inhibition of anoxia-induced injury in heart myocytes by cyclosporin-A","volume":"23","author":"Nazareth","year":"1991","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021111720074591700_B151","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1006\/jmcc.1993.1162","article-title":"Protection by cyclosporin A of ischemia reperfusion-induced damage in isolated rat hearts","volume":"25","author":"Griffiths","year":"1993","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021111720074591700_B152","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0008-6363(02)00455-8","article-title":"Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?","volume":"55","author":"Hausenloy","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B153","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cardiores.2003.09.025","article-title":"Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia\u2013reperfusion injury","volume":"60","author":"Hausenloy","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B154","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.yjmcc.2004.12.001","article-title":"Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury","volume":"38","author":"Argaud","year":"2005","journal-title":"J. Mol. Cell. 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Neurosci."},{"key":"2021111720074591700_B157","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/00004647-199907000-00002","article-title":"Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion","volume":"19","author":"Matsumoto","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2021111720074591700_B158","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/exnr.2000.7459","article-title":"Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia","volume":"165","author":"Li","year":"2000","journal-title":"Exp. 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Med."},{"key":"2021111720074591700_B166","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1074\/jbc.271.6.2929","article-title":"Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2+ ions: a proposed model for phosphate-stimulated lipid peroxidation","volume":"271","author":"Kowaltowski","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021111720074591700_B167","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","article-title":"Mitochondrial ROS-induced ROS release: an update and review","volume":"1757","author":"Zorov","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111720074591700_B168","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbabio.2007.05.008","article-title":"The role of mitochondria in protection of the heart by preconditioning","volume":"1767","author":"Halestrap","year":"2007","journal-title":"Biochim. Biophys. 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Res."},{"key":"2021111720074591700_B172","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-5793(91)80246-Y","article-title":"Effects of the general anaesthetic propofol on the Ca2+-induced permeabilization of rat liver mitochondria","volume":"279","author":"Eriksson","year":"1991","journal-title":"FEBS Lett."},{"key":"2021111720074591700_B173","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-5793(95)00610-L","article-title":"Effects of the anaesthetic propofol on the calcium-induced permeability transition of rat heart mitochondria: direct pore inhibition and shift of the gating potential","volume":"368","author":"Sztark","year":"1995","journal-title":"FEBS Lett."},{"key":"2021111720074591700_B174","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0008-6363(99)00365-X","article-title":"Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition","volume":"45","author":"Javadov","year":"2000","journal-title":"Cardiovasc. 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Physiol."},{"key":"2021111720074591700_B177","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1097\/00000539-200212000-00013","article-title":"Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in guinea pig intact hearts: reversal by 5-hydroxydecanoic acid","volume":"95","author":"Riess","year":"2002","journal-title":"Anesth. 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Thorac. Cardiovasc. Surg."},{"key":"2021111720074591700_B181","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","article-title":"Targeting antioxidants to mitochondria by conjugation to lipophilic cations","volume":"47","author":"Murphy","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2021111720074591700_B182","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00395-007-0683-y","article-title":"Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator","volume":"103","author":"Liu","year":"2008","journal-title":"Basic Res. 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Am. Coll. Cardiol."},{"key":"2021111720074591700_B197","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1161\/CIRCULATIONAHA.105.569798","article-title":"Postconditioning: a simple, clinically applicable procedure to improve revascularization in acute myocardial infarction","volume":"112","author":"Vinten-Johansen","year":"2005","journal-title":"Circulation"},{"key":"2021111720074591700_B198","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0140-6736(06)68157-9","article-title":"Postconditioning for protection of the infarcting heart","volume":"367","author":"Yellon","year":"2006","journal-title":"Lancet"},{"key":"2021111720074591700_B199","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/01.CIR.0000151290.04952.3B","article-title":"Postconditioning inhibits mitochondrial permeability transition","volume":"111","author":"Argaud","year":"2005","journal-title":"Circulation"},{"key":"2021111720074591700_B200","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.healun.2007.02.009","article-title":"Post-conditioning protects from cardioplegia and cold ischemia via inhibition of mitochondrial permeability transition pore","volume":"26","author":"Ferrera","year":"2007","journal-title":"J. Heart Lung Transplant."},{"key":"2021111720074591700_B201","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10863-008-9186-2","article-title":"Relationship between oxidative stress and mitochondrial function in the post-conditioned heart","volume":"40","author":"Correa","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"2021111720074591700_B202","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10741-007-9033-2","article-title":"Postconditioning in man","volume":"12","author":"Thibault","year":"2007","journal-title":"Heart Failure Rev."},{"key":"2021111720074591700_B203","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/153537020523000701","article-title":"Metabolic cardioprotection by pyruvate: recent progress","volume":"230","author":"Mallet","year":"2005","journal-title":"Exp. Biol. Med."},{"key":"2021111720074591700_B204","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00005344-198001000-00006","article-title":"Improvement of mitochondrial energy production in ischaemic myocardium by in vivo infusion of ruthenium red","volume":"2","author":"Peng","year":"1980","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2021111720074591700_B205","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0022-2828(82)90186-9","article-title":"The effects of ruthenium red on mitochodrial function during post-ischaemic reperfusion","volume":"14","author":"Ferrari","year":"1982","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021111720074591700_B206","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cvr\/26.1.20","article-title":"Myocardial stunning: a role for calcium antagonists during reperfusion","volume":"26","author":"Opie","year":"1992","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B207","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/00005344-199011000-00014","article-title":"Ruthenium red improves postischemic contractile function in isolated rat hearts","volume":"16","author":"Grover","year":"1990","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2021111720074591700_B208","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/cvr\/25.4.337","article-title":"Postischaemic reperfusion injury in the isolated rat heart: effect of ruthenium red","volume":"25","author":"Figueredo","year":"1991","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B209","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/01.RES.71.3.567","article-title":"Dissociation between contractile function and oxidative metabolism in postischemic myocardium: attenuation by ruthenium red administered during reperfusion","volume":"71","author":"Benzi","year":"1992","journal-title":"Circ. Res."},{"key":"2021111720074591700_B210","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0008-6363(96)88537-3","article-title":"Preischaemic as well as postischaemic application of a calcium antagonist affords cardioprotection in the isolated guinea pig heart","volume":"29","author":"Massoudy","year":"1995","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B211","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjp.0706932","article-title":"Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo","volume":"149","author":"Garc\u00eda-Rivas","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"2021111720074591700_B212","first-page":"295","article-title":"New concepts in the cardioprotective action of magnesium and taurine during the calcium paradox and ischaemia of the heart","volume":"7","author":"Suleiman","year":"1994","journal-title":"Magnesium Res."},{"key":"2021111720074591700_B213","first-page":"85","article-title":"The role of magnesium in myocardial preservation","volume":"8","author":"Lareau","year":"1994","journal-title":"Magnesium Res."},{"key":"2021111720074591700_B214","first-page":"37","article-title":"Importance of timing of magnesium administration: a study on the isolated ischemic\u2013reperfused rat heart","volume":"12","author":"Maulik","year":"1999","journal-title":"Magnesium Res."},{"key":"2021111720074591700_B215","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"2021111720074591700_B216","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2125.2000.00236.x","article-title":"Therapeutic potential of ischaemic preconditioning","volume":"50","author":"Edwards","year":"2000","journal-title":"Br. J. Clin. Pharmacol."},{"key":"2021111720074591700_B217","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol. Rev."},{"key":"2021111720074591700_B218","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cardiores.2006.01.012","article-title":"Preconditioning, postconditioning and their application to clinical cardiology","volume":"70","author":"Kloner","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"2021111720074591700_B219","first-page":"H1107","article-title":"Ischemic preconditioning protects against infarction in rat heart","volume":"263","author":"Liu","year":"1992","journal-title":"Am. J. Physiol."},{"key":"2021111720074591700_B220","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/BF00801960","article-title":"Preconditioning of the heart by repeated stunning: attenuation of post-ischemic dysfunction","volume":"87","author":"Kimura","year":"1992","journal-title":"Basic Res. Cardiol."},{"key":"2021111720074591700_B221","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s003950170041","article-title":"Delayed preconditioning of myocardium: current perspectives","volume":"96","author":"Baxter","year":"2001","journal-title":"Basic Res. Cardiol."},{"key":"2021111720074591700_B222","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cardiores.2006.02.023","article-title":"Cardiac genomic response following preconditioning stimulus","volume":"70","author":"Das","year":"2006","journal-title":"Cardiovasc. 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Res."},{"key":"2021111720074591700_B229","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.febslet.2010.02.022","article-title":"Signal transduction to the permeability transition pore","volume":"584","author":"Rasola","year":"2010","journal-title":"FEBS Lett."},{"key":"2021111720074591700_B230","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1073\/pnas.0912742107","article-title":"Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition","volume":"107","author":"Rasola","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111720074591700_B231","doi-asserted-by":"crossref","first-page":"H928","DOI":"10.1152\/ajpheart.01135.2006","article-title":"Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly, by reducing oxidative stress","volume":"293","author":"Townsend","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. 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Physiol."},{"key":"2021111720074591700_B256","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1113\/jphysiol.2002.035006","article-title":"Matrix volume measurements challenge the existence of diazoxide\/glibencamidesensitive K-ATP channels in rat mitochondria","volume":"547","author":"Das","year":"2003","journal-title":"J. Physiol."},{"key":"2021111720074591700_B257","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.bbabio.2008.04.018","article-title":"Determination of the rate of K+ movement through potassium channels in isolated rat heart and liver mitochondria","volume":"1777","author":"Bednarczyk","year":"2008","journal-title":"Biochim. Biophys. 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