{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:00:36Z","timestamp":1790218836336,"version":"4.1.0"},"reference-count":75,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:p>It is widely accepted that inflammation plays some role in the progression of chronic neurodegenerative diseases such as AD (Alzheimer's disease), but its precise role remains elusive. It has been known for many years that systemic inflammatory insults can signal to the brain to induce changes in CNS (central nervous system) function, typically grouped under the syndrome of sickness behaviour. These changes are mediated via systemic and CNS cytokine and prostaglandin synthesis. When patients with dementia suffer similar systemic inflammatory insults, delirium is a frequent consequence. This profound and acute exacerbation of cognitive dysfunction is associated with poor prognosis: accelerating cognitive decline and shortening time to permanent institutionalization and death. Therefore a better understanding of how delirium occurs during dementia and how these episodes impact on existing neurodegeneration are now important priorities. The current review summarizes the relationship between dementia, systemic inflammation and episodes of delirium and addresses the basic scientific approaches currently being pursued with respect to understanding acute cognitive dysfunction during aging and dementia. In addition, despite there being limited studies on this subject, it is becoming increasingly clear that infections and other systemic inflammatory conditions do increase the risk of AD and accelerate the progression of established dementia. These data suggest that systemic inflammation is a major contributor to the progression of dementia and constitutes an important clinical target.<\/jats:p>","DOI":"10.1042\/bst0390945","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T12:05:03Z","timestamp":1311681903000},"page":"945-953","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Systemic inflammation and delirium: important co-factors in the progression of dementia"],"prefix":"10.1042","volume":"39","author":[{"given":"Colm","family":"Cunningham","sequence":"first","affiliation":[{"name":"School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Republic of Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2011,7,20]]},"reference":[{"key":"2021111719453818000_B1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0140-6736(90)91101-F","article-title":"Anti-inflammatory drugs and Alzheimer disease","volume":"335","author":"McGeer","year":"1990","journal-title":"Lancet"},{"key":"2021111719453818000_B2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1474-4422(02)00133-3","article-title":"The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease","volume":"1","author":"Aisen","year":"2002","journal-title":"Lancet Neurol."},{"key":"2021111719453818000_B3","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/archneur.2008.65.7.nct70006","article-title":"Cognitive function over time in the Alzheimer's disease anti-inflammatory prevention trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib","volume":"65","author":"Martin","year":"2008","journal-title":"Arch. Neurol."},{"key":"2021111719453818000_B4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/archneurol.2010.136","article-title":"A summary risk score for the prediction of Alzheimer disease in elderly persons","volume":"67","author":"Reitz","year":"2010","journal-title":"Arch. Neurol."},{"key":"2021111719453818000_B5","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1001\/jama.292.18.2237","article-title":"The metabolic syndrome, inflammation, and risk of cognitive decline","volume":"292","author":"Yaffe","year":"2004","journal-title":"JAMA, J. Am. Med. 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Neurosci."},{"key":"2021111719453818000_B15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.bbi.2008.05.007","article-title":"Malaise in the water maze: untangling the effects of LPS and IL-1\u03b2 on learning and memory","volume":"22","author":"Cunningham","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"2021111719453818000_B16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3758\/BF03332100","article-title":"Behavioural consequences of prion disease targeted to the hippocampus in a mouse model of scrapie","volume":"27","author":"Betmouni","year":"1999","journal-title":"Psychobiology"},{"key":"2021111719453818000_B17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(96)00212-6","article-title":"Evidence for an early inflammatory response in the central nervous system of mice with scrapie","volume":"74","author":"Betmouni","year":"1996","journal-title":"Neuroscience"},{"key":"2021111719453818000_B18","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1046\/j.1460-9568.2003.02662.x","article-title":"Synaptic changes characterize early behavioural changes in the ME7 model of murine prion disease","volume":"17","author":"Cunningham","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"2021111719453818000_B19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0306-4522(02)00030-1","article-title":"Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease","volume":"112","author":"Combrinck","year":"2002","journal-title":"Neuroscience"},{"key":"2021111719453818000_B20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.neurobiolaging.2005.03.010","article-title":"Peripheral infection and aging interact to impair hippocampal memory consolidation","volume":"27","author":"Barrientos","year":"2006","journal-title":"Neurobiol. 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Bull."},{"key":"2021111719453818000_B27","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1093\/brain\/awn101","article-title":"Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease","volume":"131","author":"Godoy","year":"2008","journal-title":"Brain"},{"key":"2021111719453818000_B28","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1471-4159.2010.06879.x","article-title":"Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson's disease","volume":"114","author":"Villaran","year":"2010","journal-title":"J. Neurochem."},{"key":"2021111719453818000_B29","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1523\/JNEUROSCI.5376-06.2007","article-title":"Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms","volume":"27","author":"McColl","year":"2007","journal-title":"J. Neurosci."},{"key":"2021111719453818000_B30","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1523\/JNEUROSCI.0406-09.2009","article-title":"Systemic inflammatory response reactivates immune-mediated lesions in rat brain","volume":"29","author":"Serres","year":"2009","journal-title":"J. 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Scand."},{"key":"2021111719453818000_B36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bandc.2010.05.010","article-title":"Cortisol, interleukins and S100B in delirium in the elderly","volume":"74","author":"van\u00a0Munster","year":"2010","journal-title":"Brain Cogn."},{"key":"2021111719453818000_B37","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1460-9568.2008.06485.x","article-title":"Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats","volume":"28","author":"Maren","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"2021111719453818000_B38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.physbeh.2007.03.032","article-title":"Age increases vulnerability to bacterial endotoxin-induced behavioral decrements","volume":"91","author":"Kohman","year":"2007","journal-title":"Physiol. Behav."},{"key":"2021111719453818000_B39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/YCO.0b013e32833861f6","article-title":"Persistent delirium in older hospital patients","volume":"23","author":"Cole","year":"2010","journal-title":"Curr. Opin. Psychiatry"},{"key":"2021111719453818000_B40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bbi.2007.08.014","article-title":"Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system","volume":"22","author":"Chen","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"2021111719453818000_B41","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.biopsych.2008.07.024","article-title":"Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease","volume":"65","author":"Cunningham","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"2021111719453818000_B42","article-title":"Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium","author":"Murray","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"2021111719453818000_B43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1471-4159.2010.06759.x","article-title":"Cyclooxygenase-1 mediates prostaglandin E2 elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1\u03b2 expression","volume":"114","author":"Matousek","year":"2010","journal-title":"J. Neurochem."},{"key":"2021111719453818000_B44","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuron.2010.04.031","article-title":"Probing the biology of Alzheimer's disease in mice","volume":"66","author":"Ashe","year":"2010","journal-title":"Neuron"},{"key":"2021111719453818000_B45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-2094-5-37","article-title":"Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of \u03b2-amyloid generation","volume":"5","author":"Lee","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"2021111719453818000_B46","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1073\/pnas.92.7.3032","article-title":"Inflammatory processes induce \u03b2-amyloid precursor protein changes in mouse brain","volume":"92","author":"Brugg","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111719453818000_B47","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.expneurol.2007.01.003","article-title":"Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model","volume":"204","author":"Semmler","year":"2007","journal-title":"Exp. Neurol."},{"key":"2021111719453818000_B48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-2094-5-38","article-title":"Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism","volume":"5","author":"Semmler","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"2021111719453818000_B49","doi-asserted-by":"crossref","first-page":"14177","DOI":"10.1523\/JNEUROSCI.3238-09.2009","article-title":"NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits","volume":"29","author":"Weberpals","year":"2009","journal-title":"J. Neurosci."},{"key":"2021111719453818000_B50","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s00134-007-0598-y","article-title":"Brain lesions in septic shock: a magnetic resonance imaging study","volume":"33","author":"Sharshar","year":"2007","journal-title":"Intensive Care Med."},{"key":"2021111719453818000_B51","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-4-4","article-title":"Microglia activation in sepsis: a case-control study","volume":"4","author":"Lemstra","year":"2007","journal-title":"J. Neuroinflammation"},{"key":"2021111719453818000_B52","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1523\/JNEUROSCI.4786-03.2004","article-title":"Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis","volume":"24","author":"Nguyen","year":"2004","journal-title":"J. Neurosci."},{"key":"2021111719453818000_B53","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J. Neurosci."},{"key":"2021111719453818000_B54","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/jnr.22270","article-title":"Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases","volume":"88","author":"Ebert","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"2021111719453818000_B55","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1093\/emboj\/17.23.6888","article-title":"Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling","volume":"17","author":"Balachandran","year":"1998","journal-title":"EMBO J."},{"key":"2021111719453818000_B56","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1523\/JNEUROSCI.3971-09.2010","article-title":"eIF2\u03b1 phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation","volume":"30","author":"Jiang","year":"2010","journal-title":"J. Neurosci."},{"key":"2021111719453818000_B57","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ageing\/32.2.200","article-title":"Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications","volume":"32","author":"Holmes","year":"2003","journal-title":"Age Ageing"},{"key":"2021111719453818000_B58","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nri2015","article-title":"Systemic infections and inflammation affect chronic neurodegeneration","volume":"7","author":"Perry","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2021111719453818000_B59","doi-asserted-by":"crossref","first-page":"993","DOI":"10.2165\/11310910-000000000-00000","article-title":"Role of infection in the pathogenesis of Alzheimer's disease: implications for treatment","volume":"23","author":"Holmes","year":"2009","journal-title":"CNS Drugs"},{"key":"2021111719453818000_B60","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.wad.0000165511.52746.1f","article-title":"Association between dementia and infectious disease: evidence from a case-control study","volume":"19","author":"Dunn","year":"2005","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"2021111719453818000_B61","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1161\/01.STR.0000086754.32238.DA","article-title":"Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases","volume":"34","author":"Strandberg","year":"2003","journal-title":"Stroke"},{"key":"2021111719453818000_B62","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.archger.2004.04.053","article-title":"Cognitive impairment and infectious burden in the elderly","author":"Strandberg","year":"2004","journal-title":"Arch. Gerontol. Geriatr. Suppl."},{"key":"2021111719453818000_B63","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/gerona\/59.3.M268","article-title":"Predictors of cognitive decline and mortality of aged people over a 10-year period","volume":"59","author":"Tilvis","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2021111719453818000_B64","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jneuroim.2009.08.013","article-title":"TNF-\u03b1 and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects","volume":"216","author":"Kamer","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"2021111719453818000_B65","first-page":"1495","article-title":"Past exposure to vaccines and subsequent risk of Alzheimer's disease","volume":"165","author":"Verreault","year":"2001","journal-title":"Can. Med. Assoc. J."},{"key":"2021111719453818000_B66","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1532-5415.2004.52109.x","article-title":"A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease","volume":"52","author":"Loeb","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"2021111719453818000_B67","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/jnnp.74.6.788","article-title":"Systemic infection, interleukin 1\u03b2, and cognitive decline in Alzheimer's disease","volume":"74","author":"Holmes","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"2021111719453818000_B68","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1212\/WNL.0b013e3181b6bb95","article-title":"Systemic inflammation and disease progression in Alzheimer's disease","volume":"73","author":"Holmes","year":"2009","journal-title":"Neurology"},{"key":"2021111719453818000_B69","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1046\/j.1365-2389.2003.51255.x","article-title":"The prognostic significance of subsyndromal delirium in elderly medical inpatients","volume":"51","author":"Cole","year":"2003","journal-title":"J. Am. Geriatr. 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