{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:11:41Z","timestamp":1790223101035,"version":"4.1.0"},"reference-count":48,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:p>The most recently identified PLC (phospholipase C) enzymes belong to the PLC\u03b7 family. Their unique Ca2+-sensitivity and their specific appearance in neurons have attracted great attention since their discovery; however, their physiological role(s) in neurons are still yet to be established. PLC\u03b7 enzymes are expressed in the neocortex, hippocampus and cerebellum. PLC\u03b72 is also expressed at high levels in pituitary gland, pineal gland and in the retina. Driven by the specific localization of PLC\u03b7 enzymes in different brain areas, in the present paper, we discuss the roles that they may play in neural processes, including differentiation, memory formation, circadian rhythm regulation, neurotransmitter\/hormone release and the pathogenesis of neurodegenerative disorders associated with aberrant Ca2+ signalling, such as Alzheimer's disease.<\/jats:p>","DOI":"10.1042\/bst20110622","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T15:27:25Z","timestamp":1326986845000},"page":"282-286","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Putative roles for phospholipase C\u03b7 enzymes in neuronal Ca2+ signal modulation"],"prefix":"10.1042","volume":"40","author":[{"given":"Petra","family":"Popovics","sequence":"first","affiliation":[{"name":"School of Medicine, University of St Andrews, St Andrews KY16 9TF, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan\u00a0J.","family":"Stewart","sequence":"additional","affiliation":[{"name":"School of Medicine, University of St Andrews, St Andrews KY16 9TF, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"2021111720351892900_B1","first-page":"13718","article-title":"Regulation of phosphoinositide-specific phospholipase C isozymes","volume":"263","author":"Rhee","year":"1997","journal-title":"J. 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