{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:14:06Z","timestamp":1791994446702,"version":"4.4.0"},"reference-count":22,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>The stepwise progression of tau pathology [NFTs (neurofibrillary tangles) and NTs (neuropil threads)] in AD (Alzheimer's disease) is generally assumed to begin in the transentorhinal region (entorhinal stage) from which it progresses to the hippocampus (limbic stage) and to neocortical regions (neocortical stage). This stepwise progression is reflected in the NFT Braak stages. However, it has been shown recently that tau pathology is frequently seen in subcortical nuclei, in particular the LC (locus coeruleus) in over 90% of individuals under 30\u00a0years of age, suggesting that AD-associated tau pathology begins in the LC and not in the transentorhinal region. On the other hand, only minimal amounts of tau pathology are seen in the LC in cases with considerable entorhinal tau pathology, while the severity of tau pathology in the LC significantly increases with increasing NFT Braak stages. These findings suggest that the LC becomes increasingly involved during AD progression rather than representing the site initially affected. Further studies are warranted to answer the question of whether tau pathology in the LC of young individuals is associated with AD or whether it rather reflects non-specific neuronal damage.<\/jats:p>","DOI":"10.1042\/bst20120034","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T09:28:47Z","timestamp":1343035727000},"page":"711-715","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["The relationship between subcortical tau pathology and Alzheimer's disease"],"prefix":"10.1042","volume":"40","author":[{"given":"Johannes","family":"Attems","sequence":"first","affiliation":[{"name":"Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar\u00a0R.","family":"Thal","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropathology, Institute of Pathology, Center for Clinical Research, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt\u00a0A.","family":"Jellinger","sequence":"additional","affiliation":[{"name":"Institute for Clinical Neurobiology, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2012,7,20]]},"reference":[{"key":"2021111900101746500_B1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol."},{"key":"2021111900101746500_B2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"2021111900101746500_B3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"2021111900101746500_B4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","article-title":"The pathological process underlying Alzheimer's disease in individuals under thirty","volume":"121","author":"Braak","year":"2011","journal-title":"Acta Neuropathol."},{"key":"2021111900101746500_B5","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer's disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J. 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