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Recent developments suggest that the concomitant genome-wide remodelling of the gene expression programme is largely driven through epigenetic mechanisms such as post-translational histone modifications and DNA methylation. In the last few years, the distinct functions of histone modifications and of the enzymes catalysing their formation have begun to be elucidated in processes important for cardiac development, disease and cardiomyocyte proliferation. The present review explores how repressive histone modifications, in particular methylation of H3K9 (histone H3 Lys9), govern aspects of cardiac biology.<\/jats:p>","DOI":"10.1042\/bst20130012","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T15:51:46Z","timestamp":1369324306000},"page":"789-796","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Epigenetics in the heart: the role of histone modifications in cardiac remodelling"],"prefix":"10.1042","volume":"41","author":[{"given":"Asmita","family":"Tingare","sequence":"first","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Thienpont","sequence":"additional","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, U.K."},{"name":"Laboratory of Translational Genetics, Vesalius Research Center, VIB, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u00a0Llewelyn","family":"Roderick","sequence":"additional","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"2021111719203309400_B1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"2021111719203309400_B2","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2010.11.036","article-title":"C\/EBP\u03b2 controls exercise-induced cardiac growth and protects against pathological cardiac remodeling","volume":"143","author":"Bostrom","year":"2010","journal-title":"Cell"},{"key":"2021111719203309400_B3","first-page":"e154","article-title":"ACC\/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society","volume":"112","author":"Hunt","year":"2005","journal-title":"Circulation"},{"key":"2021111719203309400_B4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/01.CIR.0000048894.99865.02","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. 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