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In addition, we briefly discuss the pancreas as an example of plasticity of intrinsic progenitors and even differentiated cells. Of relevance, examples of plasticity and fate change characterize pathologies such as oesophageal metaplasia, whose possible cell origin is still debated, but has important implications as a pre-neoplastic event. Although much work remains to be done in order to unravel the full potential and plasticity of epithelial cells, exploitation of this phenomenon has already entered the clinical arena, and might provide new avenues for future cell therapy of these tissues.<\/jats:p>","DOI":"10.1042\/bst20140047","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T10:06:36Z","timestamp":1400753196000},"page":"637-644","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lineage potential, plasticity and environmental reprogramming of epithelial stem\/progenitor cells"],"prefix":"10.1042","volume":"42","author":[{"given":"Alessandro\u00a0W.","family":"Amici","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"},{"name":"Department of Experimental Surgery, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatai\u00a0O.","family":"Onikoyi","sequence":"additional","affiliation":[{"name":"School of Life and Medical Sciences, Institute of Child Health, University College London (UCL), 30 Guilford Street, London WC1N 1EH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"School of Life and Medical Sciences, Institute of Child Health, University College London (UCL), 30 Guilford Street, London WC1N 1EH, U.K."},{"name":"Institute of Immunity and Transplantation, Royal Free Hospital, University College London (UCL), Pond Street, London NW3 2QG, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"2021111719303695500_B1","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"2021111719303695500_B2","doi-asserted-by":"publisher","first-page":"14677","DOI":"10.1073\/pnas.0507250102","article-title":"Long-term renewal of hair follicles from clonogenic multipotent stem cells","volume":"102","author":"Claudinot","year":"2005","journal-title":"Proc. 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