{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:12:57Z","timestamp":1787163177603,"version":"build-2736575974"},"reference-count":60,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:p>Malaria kills more than half a million people each year. There is no vaccine, and recent reports suggest that resistance is developing to the antimalarial regimes currently recommended by the World Health Organization. New drugs are therefore needed to ensure malaria treatment options continue to be available. The intra-erythrocytic stage of the malaria parasite's life cycle is dependent on an extracellular supply of pantothenate (vitamin B5), the precursor of CoA (coenzyme A). It has been known for many years that proliferation of the parasite during this stage of its life cycle can be inhibited with pantothenate analogues. We have shown recently that pantothenamides, a class of pantothenate analogues with antibacterial activity, inhibit parasite proliferation at submicromolar concentrations and do so competitively with pantothenate. These compounds, however, are degraded, and therefore rendered inactive, by the enzyme pantetheinase (vanin), which is present in serum. In the present mini-review, we discuss the two strategies that have been put forward to overcome pantetheinase-mediated degradation of pantothenamides. The strategies effectively provide an opportunity for pantothenamides to be tested in\u00a0vivo. We also put forward our \u2018blueprint\u2019 for the further development of pantothenamides (and other pantothenate analogues) as potential antimalarials.<\/jats:p>","DOI":"10.1042\/bst20140158","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T07:55:37Z","timestamp":1407743737000},"page":"1087-1093","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides"],"prefix":"10.1042","volume":"42","author":[{"given":"Kevin\u00a0J.","family":"Saliba","sequence":"first","affiliation":[{"name":"Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia"},{"name":"Medical School, The Australian National University, Canberra, ACT 0200, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Spry","sequence":"additional","affiliation":[{"name":"Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia"},{"name":"Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"2021111818225034300_B1","volume-title":"World Malaria Report","author":"World Health Organization","year":"2013"},{"key":"2021111818225034300_B2","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/joim.12223","article-title":"The path of malaria vaccine development: challenges and perspectives","volume":"275","author":"Arama","year":"2014","journal-title":"J. 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