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At the doses required to induce therapeutic benefit, VEGF causes new vascular growth essentially without sprouting, but rather through the alternative process of intussusception, or vascular splitting. In the present article, we briefly review the therapeutic implications of controlling VEGF dose on one hand and pericyte recruitment on the other, as well as the key features of intussusceptive angiogenesis and its regulation.<\/jats:p>","DOI":"10.1042\/bst20140234","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T11:14:41Z","timestamp":1416827681000},"page":"1637-1642","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis"],"prefix":"10.1042","volume":"42","author":[{"given":"Roberto","family":"Gianni-Barrera","sequence":"first","affiliation":[{"name":"Cell and Gene Therapy, Department of Biomedicine, University of Basel, and Department of Surgery, Basel University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland"},{"name":"Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee, D-18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariateresa","family":"Bartolomeo","sequence":"additional","affiliation":[{"name":"Cell and Gene Therapy, Department of Biomedicine, University of Basel, and Department of Surgery, Basel University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[{"name":"Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee, D-18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Djonov","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH-3000 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Banfi","sequence":"additional","affiliation":[{"name":"Cell and Gene Therapy, Department of Biomedicine, University of Basel, and Department of Surgery, Basel University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"2021111719295032500_B1","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1161\/01.cir.0000441139.02102.80","article-title":"Heart disease and stroke statistics\u20132014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"2021111719295032500_B2","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-society consensus for the management of peripheral arterial disease (TASC II)","volume":"45","author":"Norgren","year":"2007","journal-title":"J. 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