{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:03:28Z","timestamp":1766048608130},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:p>The cardiovascular system is typically a sterile environment; however entry of a microorganism into the circulation can cause potentially life threatening cardiac and\/or vascular disease. Staphylococcus aureus endothelial cell interactions are arguably the most important interactions in the pathogenesis of cardiovascular infection. These interactions can trigger cardiac valve destruction in the case of endocarditis, multi-organ dysfunction in the case of sepsis and coagulopathy. Here, we review the interactions between S. aureus and endothelial cells and discuss the implications of these interactions in the progression of cardiovascular infection.<\/jats:p>","DOI":"10.1042\/bst20140309","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T16:51:05Z","timestamp":1439311865000},"page":"715-719","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dysregulation of the endothelium following<i>Staphylococcus aureus<\/i>infection"],"prefix":"10.1042","volume":"43","author":[{"given":"Steven\u00a0W.","family":"Kerrigan","sequence":"first","affiliation":[{"name":"School of Pharmacy, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland"},{"name":"Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cormac","family":"McDonnell","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"2021111821213804500_B1","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/j.1365-3164.2009.00825.x","article-title":"Colonization and infection of the human host by staphylococci: adhesion, survival and immune evasion","volume":"20","author":"Foster","year":"2009","journal-title":"Vet. 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