{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:26:33Z","timestamp":1789622793368,"version":"build-2803163510"},"reference-count":43,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:p>TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type\u00a0IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.<\/jats:p>","DOI":"10.1042\/bst20140311","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T15:15:34Z","timestamp":1432653334000},"page":"442-446","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Regulation of TRPML1 function"],"prefix":"10.1042","volume":"43","author":[{"given":"Helen","family":"Waller-Evans","sequence":"first","affiliation":[{"name":"School of Biosciences, Sir Martin Evans building, Cardiff University, Museum Avenue, Cardiff, CF15 8AZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emyr","family":"Lloyd-Evans","sequence":"additional","affiliation":[{"name":"School of Biosciences, Sir Martin Evans building, Cardiff University, Museum Avenue, Cardiff, CF15 8AZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"2021111719365735400_B1","doi-asserted-by":"publisher","first-page":"43218","DOI":"10.1074\/jbc.M508210200","article-title":"TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage","volume":"280","author":"Kiselyov","year":"2005","journal-title":"J. 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