{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:54:13Z","timestamp":1791338053439,"version":"4.3.1"},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:p>The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)\/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand its function and regulation by endogenous and synthetic ligands. We have recently determined the structure of mammalian TSPO\/PBR in complex with the diagnostic ligand PK11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; Jaremko et al. (2014) Science 343, 1363\u20131366], providing for the first time atomic-level insight into the conformation of this protein, which is up-regulated in various pathological conditions including Alzheimer's disease and Parkinson's disease. Here, we review the studies which have probed the structural properties of mammalian TSPO\/PBR as well as the homologues bacterial tryptophan-rich sensory proteins (TspOs) over the years and provide detailed insight into the 3D structure of mouse TSPO (mTSPO)\/PBR in complex with PK11195.<\/jats:p>","DOI":"10.1042\/bst20150029","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T16:51:05Z","timestamp":1439311865000},"page":"566-571","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Structure of the mammalian TSPO\/PBR protein"],"prefix":"10.1042","volume":"43","author":[{"given":"Mariusz","family":"Jaremko","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie, G\u00f6ttingen 37077, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Jaremko","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie, G\u00f6ttingen 37077, Germany"},{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE), G\u00f6ttingen 37077, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Jaipuria","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie, G\u00f6ttingen 37077, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Becker","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie, G\u00f6ttingen 37077, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Zweckstetter","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biophysikalische Chemie, G\u00f6ttingen 37077, Germany"},{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE), G\u00f6ttingen 37077, Germany"},{"name":"Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center, G\u00f6ttingen 37077, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"2021111821225958000_B2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/bpa.12196","article-title":"The 18\u00a0kDa translocator protein, microglia and neuroinflammation","volume":"24","author":"Liu","year":"2014","journal-title":"Brain Pathol."},{"key":"2021111821225958000_B3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0026-895X(25)09743-3","article-title":"Molecular characterization and mitochondrial density of a recognition site for peripheral-type benzodiazepine ligands","volume":"34","author":"Antkiewicz-Michaluk","year":"1988","journal-title":"Mol. 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