{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:03:03Z","timestamp":1789020183207,"version":"build-2803163510"},"reference-count":73,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:p>Type 2 diabetes is a complex disease. It results from a failure of the body to maintain energy homoeostasis. Multicellular organisms have evolved complex strategies to preserve a relatively stable internal nutrient environment, despite fluctuations in external nutrient availability. This complex strategy involves the co-ordinated responses of multiple organs to promote storage or mobilization of energy sources according to the availability of nutrients and cellular bioenergetics needs. The endocrine pancreas plays a central role in these processes by secreting insulin and glucagon. When this co-ordinated effort fails, hyperglycaemia and hyperlipidaemia develops, characterizing a state of metabolic imbalance and ultimately overt diabetes. Although diabetes is most likely a collection of diseases, scientists are starting to identify genetic components and environmental triggers. Genome-wide association studies revealed that by and large, gene variants associated with type\u00a02 diabetes are implicated in pancreatic \u03b2-cell function, suggesting that the \u03b2-cell may be the weakest link in the chain of events that results in diabetes. Thus, it is critical to understand how environmental cues affect the \u03b2-cell. Phosphoinositides are important \u2018decoders\u2019 of environmental cues. As such, these lipids have been implicated in cellular responses to a wide range of growth factors, hormones, stress agents, nutrients and metabolites. Here we will review some of the well-established and potential new roles for phosphoinositides in \u03b2-cell function\/dysfunction and discuss how our knowledge of phosphoinositide signalling could aid in the identification of potential strategies for treating or preventing type\u00a02 diabetes.<\/jats:p>","DOI":"10.1042\/bst20150229","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T16:01:21Z","timestamp":1455033681000},"page":"293-298","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phosphoinositide signalling in type\u00a02 diabetes: a \u03b2-cell perspective"],"prefix":"10.1042","volume":"44","author":[{"given":"Lucia\u00a0E.","family":"Rameh","sequence":"first","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude\u00a0T.","family":"Deeney","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"2021111719542634100_B1","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1098\/rstb.2005.1762","article-title":"Glucose-sensing mechanisms in pancreatic beta-cells","volume":"360","author":"MacDonald","year":"2005","journal-title":"Philos. 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