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Ribosomopathies, which occur due to mutations in proteins involved in the global process of ribosome biogenesis, result in tissue-specific defects. The questions posed by this dichotomy and the steps taken to address these questions are therefore the focus of this review: How can tissue-specific disorders result from alterations in global processes? Could ribosome specialization account for this difference?<\/jats:p>","DOI":"10.1042\/bst20160064","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T12:27:21Z","timestamp":1471264041000},"page":"1035-1044","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Probing the mechanisms underlying human diseases in making ribosomes"],"prefix":"10.1042","volume":"44","author":[{"given":"Katherine\u00a0I.","family":"Farley","sequence":"first","affiliation":[{"name":"Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan\u00a0J.","family":"Baserga","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06520, U.S.A."},{"name":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, U.S.A."},{"name":"Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"2021111719512847200_B1","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1182\/blood-2014-10-569616","article-title":"Ribosomopathies and the paradox of cellular hypo- to hyperproliferation","volume":"125","author":"De Keersmaecker","year":"2015","journal-title":"Blood"},{"key":"2021111719512847200_B2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/ng.2508","article-title":"Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia","volume":"45","author":"De Keersmaecker","year":"2013","journal-title":"Nat. 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