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Administration of recombinant BMP9 reverses experimental PAH in preclinical rodent models. Dalantercept, an Fc-fusion protein of the extracellular domain of ALK1 and a ligand trap for BMP9 and BMP10, is in phase II clinical trials for anti-tumour angiogenesis. Understanding the regulation of BMP9 and BMP10, at both gene and protein levels, under physiological and pathological conditions, will reveal essential information and potential novel prognostic markers for the BMP9\/BMP10-targeted therapies.<\/jats:p>","DOI":"10.1042\/bst20160083","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T12:27:21Z","timestamp":1471264041000},"page":"1135-1141","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Regulation of the ALK1 ligands, BMP9 and BMP10"],"prefix":"10.1042","volume":"44","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"The Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard\u00a0M.","family":"Salmon","sequence":"additional","affiliation":[{"name":"The Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas\u00a0W.","family":"Morrell","sequence":"additional","affiliation":[{"name":"The Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"2021111719544881800_B1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cytogfr.2015.12.005","article-title":"BMP signaling in vascular biology and dysfunction","volume":"27","author":"Garcia de Vinuesa","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"2021111719544881800_B2","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1182\/blood-2006-07-034124","article-title":"Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells","volume":"109","author":"David","year":"2007","journal-title":"Blood"},{"key":"2021111719544881800_B3","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1093\/hmg\/ddt216","article-title":"The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations","volume":"22","author":"Dunmore","year":"2013","journal-title":"Hum. 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