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We review the computational studies, with a focus on molecular dynamics (MD) simulations performed on RNA models mimicking the 2-DOS aminoglycoside binding site in the small ribosomal subunit. We also briefly discuss thermodynamics of interactions of these aminoglycosides with their 16S RNA target.<\/jats:p>","DOI":"10.1042\/bst20160087","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T12:27:21Z","timestamp":1471264041000},"page":"987-993","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Interactions of aminoglycoside antibiotics with rRNA"],"prefix":"10.1042","volume":"44","author":[{"given":"Joanna","family":"Trylska","sequence":"first","affiliation":[{"name":"Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Kulik","sequence":"additional","affiliation":[{"name":"Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland"},{"name":"Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"2021111719502759700_B1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00253-005-0279-0","article-title":"Molecular understanding of aminoglycoside action and resistance","volume":"70","author":"Jana","year":"2006","journal-title":"Appl. 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