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EOGT and OGT are in separate cellular compartments and have mostly distinct substrates, although both can act on cytoplasmic (OGT) and lumenal (EOGT) domains of transmembrane proteins. The present review will describe known substrates of EOGT and biological roles for EOGT in Drosophila and humans. Mutations in EOGT that give rise to Adams\u2013Oliver Syndrome in humans will also be discussed.<\/jats:p>","DOI":"10.1042\/bst20160165","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T11:35:20Z","timestamp":1492083320000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["EOGT and <i>O<\/i>-GlcNAc on secreted and membrane proteins"],"prefix":"10.1042","volume":"45","author":[{"given":"Shweta","family":"Varshney","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"2021111818014449800_BST-2016-0165CC1","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1016\/S0021-9258(17)43295-9","article-title":"Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. 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