{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:39:44Z","timestamp":1790714384903,"version":"4.1.0"},"reference-count":109,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":629,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:p>Bacterial life is harsh and involves numerous environmental and internal challenges that are perceived as stresses. Consequently, adequate responses to survive, cope with, and counteract stress conditions have evolved. In the last few decades, a class of small, non-coding RNAs (sRNAs) has been shown to be involved as key players in stress responses. This review will discuss \u2014 primarily from an enterobacterial perspective \u2014 selected stress response pathways that involve antisense-type sRNAs. These include themes of how bacteria deal with severe envelope stress, threats of DNA damage, problems with poisoning due to toxic sugar intermediates, issues of iron homeostasis, and nutrient limitation\/starvation. The examples discussed highlight how stress relief can be achieved, and how sRNAs act mechanistically in regulatory circuits. For some cases, we will propose scenarios that may suggest why contributions from post-transcriptional control by sRNAs, rather than transcriptional control alone, appear to be a beneficial and universally selected feature.<\/jats:p>","DOI":"10.1042\/bst20160363","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T00:10:29Z","timestamp":1509754229000},"page":"1203-1212","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Impact of bacterial sRNAs in stress responses"],"prefix":"10.1042","volume":"45","author":[{"given":"Erik","family":"Holmqvist","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Uppsala University, Box 596, Uppsala S-75124, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Gerhart H.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Uppsala University, Box 596, Uppsala S-75124, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"2021111720382547300_BST-2016-0363CC1","doi-asserted-by":"publisher","first-page":"484","DOI":"10.4161\/rna.28452","article-title":"Small regulatory RNAs in Archaea","volume":"11","author":"Babski","year":"2014","journal-title":"RNA Biol."},{"key":"2021111720382547300_BST-2016-0363CC2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.4161\/rna.28036","article-title":"Small regulatory RNAs from low-GC Gram-positive bacteria","volume":"11","author":"Brantl","year":"2014","journal-title":"RNA Biol."},{"key":"2021111720382547300_BST-2016-0363CC3","doi-asserted-by":"publisher","first-page":"a003798","DOI":"10.1101\/cshperspect.a003798","article-title":"Bacterial small RNA regulators: versatile roles and rapidly evolving variations","volume":"3","author":"Gottesman","year":"2011","journal-title":"Cold Spring Harb. 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