{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:01:30Z","timestamp":1792641690345,"version":"4.5.0"},"reference-count":102,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":671,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:p>Birth asphyxia in term neonates affects 1\u20132\/1000 live births and results in the development of hypoxic\u2013ischaemic encephalopathy with devastating life-long consequences. The majority of neuronal cell death occurs with a delay, providing the potential of a treatment window within which to act. Currently, treatment options are limited to therapeutic hypothermia which is not universally successful. To identify new interventions, we need to understand the molecular mechanisms underlying the injury. Here, we provide an overview of the contribution of both oxidative stress and endoplasmic reticulum stress in the development of neonatal brain injury and identify current preclinical therapeutic strategies.<\/jats:p>","DOI":"10.1042\/bst20170017","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T00:11:47Z","timestamp":1506125507000},"page":"1067-1076","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Oxidative stress and endoplasmic reticulum (ER) stress in the development of neonatal hypoxic\u2013ischaemic brain injury"],"prefix":"10.1042","volume":"45","author":[{"given":"Claire","family":"Thornton","sequence":"first","affiliation":[{"name":"Perinatal Brain Injury Group, Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas\u2019 Hospital, London SE1 7EH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana A.","family":"Baburamani","sequence":"additional","affiliation":[{"name":"Perinatal Brain Injury Group, Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas\u2019 Hospital, London SE1 7EH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Kichev","sequence":"additional","affiliation":[{"name":"Perinatal Brain Injury Group, Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas\u2019 Hospital, London SE1 7EH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hagberg","sequence":"additional","affiliation":[{"name":"Perinatal Brain Injury Group, Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas\u2019 Hospital, London SE1 7EH, U.K."},{"name":"Perinatal Center, Institute of for Clinical Sciences and Physiology and Neurosciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg 41685, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"2021111720274145700_BST-2017-0017CC1","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0140-6736(03)12658-X","article-title":"Origin and timing of brain lesions in term infants with neonatal encephalopathy","volume":"361","author":"Cowan","year":"2003","journal-title":"Lancet"},{"key":"2021111720274145700_BST-2017-0017CC2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1017\/S0012162205000575","article-title":"Cerebral palsy following term newborn encephalopathy: a population-based study","volume":"47","author":"Badawi","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"2021111720274145700_BST-2017-0017CC3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/ana.20557","article-title":"Predictors of outcome in perinatal arterial stroke: a population-based study","volume":"58","author":"Lee","year":"2005","journal-title":"Ann. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic\u2013ischaemic encephalopathy: a nested substudy of a randomised controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol."},{"key":"2021111720274145700_BST-2017-0017CC5","doi-asserted-by":"publisher","first-page":"F304","DOI":"10.1136\/archdischild-2012-301768","article-title":"Antemortem cranial MRI compared with postmortem histopathologic examination of the brain in term infants with neonatal encephalopathy following perinatal asphyxia","volume":"98","author":"Alderliesten","year":"2013","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"2021111720274145700_BST-2017-0017CC6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.earlhumdev.2010.05.014","article-title":"Magnetic resonance imaging in hypoxic-ischaemic encephalopathy","volume":"86","author":"Rutherford","year":"2010","journal-title":"Early Hum. Dev."},{"key":"2021111720274145700_BST-2017-0017CC7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2021111720274145700_BST-2017-0017CC8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0165-3806(97)00036-9","article-title":"Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia\u2013ischemia: a light microscopic study","volume":"100","author":"Towfighi","year":"1997","journal-title":"Dev. Brain Res."},{"key":"2021111720274145700_BST-2017-0017CC9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/S0002-9378(13)70305-3","article-title":"Increased vulnerability to neuronal damage after umbilical cord occlusion in fetal sheep with advancing gestation","volume":"170","author":"Mallard","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021111720274145700_BST-2017-0017CC10","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1177\/08830738050200120301","article-title":"Neuropathologic substrate of cerebral palsy","volume":"20","author":"Folkerth","year":"2005","journal-title":"J. Child Neurol."},{"key":"2021111720274145700_BST-2017-0017CC11","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ana.22419","article-title":"Neuronal cell death in neonatal hypoxia-ischemia","volume":"69","author":"Northington","year":"2011","journal-title":"Ann. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC12","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/BF02454148","article-title":"Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain","volume":"113","author":"Blumberg","year":"1997","journal-title":"Exp. Brain Res."},{"key":"2021111720274145700_BST-2017-0017CC13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.nbd.2015.09.011","article-title":"Perinatal brain damage: the term infant","volume":"92","author":"Hagberg","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"2021111720274145700_BST-2017-0017CC14","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/00004647-199802000-00014","article-title":"Temporal changes of regional glucose use, blood flow, and microtubule-associated protein 2 immunostaining after hypoxia\u2013ischemia in the immature rat brain","volume":"18","author":"Gilland","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2021111720274145700_BST-2017-0017CC15","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1203\/00006450-199412000-00003","article-title":"Delayed (\u2018secondary\u2019) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy","volume":"36","author":"Lorek","year":"1994","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC16","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1474-4422(13)70261-8","article-title":"Mitochondria: hub of injury responses in the developing brain","volume":"13","author":"Hagberg","year":"2014","journal-title":"Lancet Neurol."},{"key":"2021111720274145700_BST-2017-0017CC17","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.neuroscience.2007.06.060","article-title":"Failure to complete apoptosis following neonatal hypoxia\u2013ischemia manifests as \u2018continuum\u2019 phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain","volume":"149","author":"Northington","year":"2007","journal-title":"Neuroscience"},{"key":"2021111720274145700_BST-2017-0017CC18","first-page":"70","article-title":"Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum","volume":"378","author":"Portera-Cailliau","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0165-3806(00)00110-3","article-title":"Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats","volume":"125","author":"Puka-Sundvall","year":"2000","journal-title":"Dev. Brain Res."},{"key":"2021111720274145700_BST-2017-0017CC20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cca.2015.01.026","article-title":"Role of mitochondria in apoptotic and necroptotic cell death in the developing brain","volume":"451","author":"Thornton","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"2021111720274145700_BST-2017-0017CC21","doi-asserted-by":"publisher","first-page":"506320","DOI":"10.1155\/2012\/506320","article-title":"Molecular mechanisms of neonatal brain injury","volume":"2012","author":"Thornton","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"2021111720274145700_BST-2017-0017CC22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/sj.cdd.4401545","article-title":"The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia\u2013ischemia","volume":"12","author":"Zhu","year":"2005","journal-title":"Cell Death Differ."},{"key":"2021111720274145700_BST-2017-0017CC23","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1523\/JNEUROSCI.5832-08.2009","article-title":"Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"2021111720274145700_BST-2017-0017CC24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000047087","article-title":"Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia","volume":"79","author":"Wang","year":"2001","journal-title":"Neonatology"},{"key":"2021111720274145700_BST-2017-0017CC25","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1084\/jem.20070193","article-title":"Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia","volume":"204","author":"Zhu","year":"2007","journal-title":"J. Exp. Med."},{"key":"2021111720274145700_BST-2017-0017CC26","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.cdd.4402053","article-title":"Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia","volume":"14","author":"Zhu","year":"2007","journal-title":"Cell Death Differ."},{"key":"2021111720274145700_BST-2017-0017CC27","doi-asserted-by":"publisher","first-page":"257563","DOI":"10.1155\/2012\/257563","article-title":"Programmed necrosis: a prominent mechanism of cell death following neonatal brain injury","volume":"2012","author":"Chavez-Valdez","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"2021111720274145700_BST-2017-0017CC28","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3390\/biom5020472","article-title":"Biological activities of reactive oxygen and nitrogen species: oxidative stress versus signal transduction","volume":"5","author":"Weidinger","year":"2015","journal-title":"Biomolecules"},{"key":"2021111720274145700_BST-2017-0017CC29","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1161\/STROKEAHA.114.006170","article-title":"NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia","volume":"45","author":"Knox","year":"2014","journal-title":"Stroke"},{"issue":"Suppl 3","key":"2021111720274145700_BST-2017-0017CC30","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/14767058.2010.509940","article-title":"Oxidative stress and antioxidant strategies in newborns","volume":"23","author":"Perrone","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"2021111720274145700_BST-2017-0017CC31","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1089\/ars.2010.3581","article-title":"Neuronal death and oxidative stress in the developing brain","volume":"14","author":"Ikonomidou","year":"2011","journal-title":"Antiox. Redox Signal."},{"key":"2021111720274145700_BST-2017-0017CC32","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1159\/000046143","article-title":"Oxidant mechanisms in neonatal hypoxia-ischemia","volume":"23","author":"Ferriero","year":"2001","journal-title":"Dev. Neurosci."},{"key":"2021111720274145700_BST-2017-0017CC33","doi-asserted-by":"publisher","first-page":"542976","DOI":"10.1155\/2012\/542976","article-title":"Hypoxic-ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria","volume":"2012","author":"Ten","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"2021111720274145700_BST-2017-0017CC34","doi-asserted-by":"publisher","first-page":"e0160870","DOI":"10.1371\/journal.pone.0160870","article-title":"DHA but not EPA emulsions preserve neurological and mitochondrial function after brain hypoxia-ischemia in neonatal mice","volume":"11","author":"Mayurasakorn","year":"2016","journal-title":"PLoS ONE"},{"key":"2021111720274145700_BST-2017-0017CC35","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.3109\/14767058.2015.1081889","article-title":"Status of vitamin D, antioxidant enzymes, and antioxidant substances in neonates with neonatal hypoxic-ischemic encephalopathy","volume":"29","author":"Mutlu","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"2021111720274145700_BST-2017-0017CC36","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.pediatrneurol.2010.05.009","article-title":"Whole body hypothermia and oxidative stress in babies with hypoxic-ischemic brain injury","volume":"43","author":"Perrone","year":"2010","journal-title":"Pediatr. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC37","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.3390\/ijms17122078","article-title":"Oxidative stress in hypoxic-ischemic encephalopathy: molecular mechanisms and therapeutic strategies","volume":"17","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2021111720274145700_BST-2017-0017CC38","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.freeradbiomed.2005.08.040","article-title":"Free radicals, mitochondria, and hypoxia\u2013ischemia in the developing brain","volume":"40","author":"Blomgren","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"2021111720274145700_BST-2017-0017CC39","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/(SICI)1097-4547(19990401)56:1&lt;60::AID-JNR8&gt;3.0.CO;2-A","article-title":"Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat","volume":"56","author":"Palmer","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"2021111720274145700_BST-2017-0017CC40","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.redox.2015.06.007","article-title":"Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism","volume":"6","author":"Lu","year":"2015","journal-title":"Redox Biol."},{"key":"2021111720274145700_BST-2017-0017CC41","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jneuroim.2005.06.031","article-title":"Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia\u2013ischemia in the neonatal rat brain","volume":"167","author":"van den Tweel","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"2021111720274145700_BST-2017-0017CC42","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1090-3798(98)80004-4","article-title":"Nitric oxide in developing brain","volume":"2","author":"Ergenekon","year":"1998","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC43","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1006\/nbdi.1995.0016","article-title":"Expression of neuronal nitric oxide synthase corresponds to regions of selective vulnerability to hypoxia-ischaemia in the developing rat brain","volume":"2","author":"Black","year":"1995","journal-title":"Neurobiol. Dis."},{"key":"2021111720274145700_BST-2017-0017CC44","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1006\/nbdi.1996.0006","article-title":"Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic\u2013ischemic injury","volume":"3","author":"Ferriero","year":"1996","journal-title":"Neurobiol. Dis."},{"key":"2021111720274145700_BST-2017-0017CC45","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0165-3806(00)00088-2","article-title":"Nitric oxide synthase activity and inhibition after neonatal hypoxia ischemia in the mouse brain","volume":"123","author":"Muramatsu","year":"2000","journal-title":"Dev. Brain Res."},{"key":"2021111720274145700_BST-2017-0017CC46","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1203\/00006450-199512000-00014","article-title":"Selective destruction of nitric oxide synthase neurons with quisqualate reduces damage after hypoxia-ischemia in the neonatal rat","volume":"38","author":"Ferriero","year":"1995","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijdevneu.2007.08.010","article-title":"Genetic and pharmacologic manipulation of oxidative stress after neonatal hypoxia-ischemia","volume":"26","author":"Sheldon","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"key":"2021111720274145700_BST-2017-0017CC48","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1203\/00006450-199602000-00003","article-title":"Brain injury after perinatal hypoxia-ischemia is exacerbated in copper\/zinc superoxide dismutase transgenic mice","volume":"39","author":"Ditelberg","year":"1996","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC49","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.nbd.2008.04.003","article-title":"Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice","volume":"31","author":"Doverhag","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"2021111720274145700_BST-2017-0017CC50","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"2021111720274145700_BST-2017-0017CC51","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1096\/fj.03-0012com","article-title":"Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria","volume":"17","author":"Petrosillo","year":"2003","journal-title":"FASEB J."},{"key":"2021111720274145700_BST-2017-0017CC52","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0014-5793(01)03206-9","article-title":"Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis","volume":"509","author":"Petrosillo","year":"2001","journal-title":"FEBS Lett."},{"key":"2021111720274145700_BST-2017-0017CC53","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nchembio727","article-title":"Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors","volume":"1","author":"Kagan","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"2021111720274145700_BST-2017-0017CC54","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.1038\/sj.onc.1204575","article-title":"The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal","volume":"20","author":"Vieira","year":"2001","journal-title":"Oncogene"},{"key":"2021111720274145700_BST-2017-0017CC55","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"2021111720274145700_BST-2017-0017CC56","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.cell.2004.05.008","article-title":"Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain","volume":"117","author":"Ricci","year":"2004","journal-title":"Cell"},{"key":"2021111720274145700_BST-2017-0017CC57","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/ana.10072","article-title":"Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge","volume":"51","author":"Husson","year":"2002","journal-title":"Ann. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC58","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1203\/01.pdr.0000252546.20451.1a","article-title":"Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion","volume":"61","author":"Welin","year":"2007","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC59","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1203\/pdr.0b013e3180332cec","article-title":"A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats","volume":"61","author":"Kellert","year":"2007","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC60","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000105473","article-title":"Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke","volume":"29","author":"Gonzalez","year":"2007","journal-title":"Dev. Neurosci."},{"key":"2021111720274145700_BST-2017-0017CC61","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000472710","article-title":"Erythropoietin treatment exacerbates moderate injury after hypoxia-ischemia in neonatal superoxide dismutase transgenic mice","volume":"39","author":"Sheldon","year":"2017","journal-title":"Dev. Neurosci."},{"key":"2021111720274145700_BST-2017-0017CC62","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000467391","article-title":"The differential effects of erythropoietin exposure to oxidative stress on microglia and astrocytes in vitro","volume":"39","author":"Pathipati","year":"2017","journal-title":"Dev. Neurosci."},{"key":"2021111720274145700_BST-2017-0017CC63","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1203\/00006450-199304000-00018","article-title":"Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats","volume":"33","author":"Palmer","year":"1993","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC64","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3390\/ijms18020265","article-title":"Role of antioxidants in neonatal hypoxic\u2013ischemic brain injury: new therapeutic approaches","volume":"18","author":"Arteaga","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2021111720274145700_BST-2017-0017CC65","doi-asserted-by":"publisher","first-page":"79247","DOI":"10.18632\/oncotarget.13018","article-title":"Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia","volume":"7","author":"Pan","year":"2016","journal-title":"Oncotarget"},{"key":"2021111720274145700_BST-2017-0017CC66","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neures.2016.01.008","article-title":"Sex-specific effects of N-acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia","volume":"108","author":"Nie","year":"2016","journal-title":"Neurosci. Res."},{"key":"2021111720274145700_BST-2017-0017CC67","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1203\/PDR.0b013e31817cfcc0","article-title":"Effects of postresuscitation N-acetylcysteine on cerebral free radical production and perfusion during reoxygenation of hypoxic newborn piglets","volume":"64","author":"Lee","year":"2008","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC68","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s00134-007-0880-z","article-title":"Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain","volume":"34","author":"Lee","year":"2008","journal-title":"Intensive Care Med."},{"key":"2021111720274145700_BST-2017-0017CC69","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1126\/scitranslmed.3003162","article-title":"Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model","volume":"4","author":"Kannan","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"2021111720274145700_BST-2017-0017CC70","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2021111720274145700_BST-2017-0017CC71","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature17041","article-title":"Protein misfolding in the endoplasmic reticulum as a conduit to human disease","volume":"529","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"2021111720274145700_BST-2017-0017CC72","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/ncb3184","article-title":"Proteostasis control by the unfolded protein response","volume":"17","author":"Hetz","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"2021111720274145700_BST-2017-0017CC73","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1089\/ars.2009.2485","article-title":"Role of the unfolded protein response regulator GRP78\/BiP in development, cancer, and neurological disorders","volume":"11","author":"Wang","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"2021111720274145700_BST-2017-0017CC74","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.tcb.2013.06.005","article-title":"IRE1: ER stress sensor and cell fate executor","volume":"23","author":"Chen","year":"2013","journal-title":"Trends Cell Biol."},{"key":"2021111720274145700_BST-2017-0017CC75","doi-asserted-by":"publisher","first-page":"e1822","DOI":"10.1038\/cddis.2015.183","article-title":"Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis."},{"key":"2021111720274145700_BST-2017-0017CC76","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1111\/febs.13598","article-title":"Cell death induced by endoplasmic reticulum stress","volume":"283","author":"Iurlaro","year":"2016","journal-title":"FEBS J."},{"key":"2021111720274145700_BST-2017-0017CC77","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1203\/PDR.0b013e3181baa083","article-title":"Endoplasmic reticulum stress, inflammation, and perinatal brain damage","volume":"66","author":"Bueter","year":"2009","journal-title":"Pediatr. Res."},{"key":"2021111720274145700_BST-2017-0017CC78","doi-asserted-by":"publisher","first-page":"e149","DOI":"10.1038\/cddis.2011.31","article-title":"Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12","volume":"2","author":"Badiola","year":"2011","journal-title":"Cell Death Dis."},{"key":"2021111720274145700_BST-2017-0017CC79","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1124\/jpet.115.230359","article-title":"Notoginsenoside R1 protects against neonatal cerebral hypoxic-ischemic injury through estrogen receptor-dependent activation of endoplasmic reticulum stress pathways","volume":"357","author":"Wang","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021111720274145700_BST-2017-0017CC80","first-page":"275","article-title":"Intranasal basic fibroblast growth factor attenuates endoplasmic reticulum stress and brain injury in neonatal hypoxic-ischaemic injury","volume":"9","author":"Lin","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"2021111720274145700_BST-2017-0017CC81","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.expneurol.2014.03.002","article-title":"Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia\u2013ischemia: role of protein synthesis and autophagic pathways","volume":"255","author":"Carloni","year":"2014","journal-title":"Exp. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC82","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/cdd.2010.152","article-title":"Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways","volume":"18","author":"Zhang","year":"2011","journal-title":"Cell Death Differ."},{"key":"2021111720274145700_BST-2017-0017CC83","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1161\/STROKEAHA.110.589051","article-title":"Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury","volume":"41","author":"Wang","year":"2010","journal-title":"Stroke"},{"key":"2021111720274145700_BST-2017-0017CC84","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.cell.2007.04.027","article-title":"ER stress triggers apoptosis by activating BH3-only protein Bim","volume":"129","author":"Puthalakath","year":"2007","journal-title":"Cell"},{"key":"2021111720274145700_BST-2017-0017CC85","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"key":"2021111720274145700_BST-2017-0017CC86","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s10495-011-0673-2","article-title":"ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2","volume":"17","author":"Mart\u00edn-P\u00e9rez","year":"2012","journal-title":"Apoptosis"},{"key":"2021111720274145700_BST-2017-0017CC87","doi-asserted-by":"publisher","first-page":"9430","DOI":"10.1074\/jbc.M113.512350","article-title":"Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation","volume":"289","author":"Kichev","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2021111720274145700_BST-2017-0017CC88","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.bbi.2009.09.008","article-title":"Inhibition of the JNK\/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic\u2013ischemic brain injury","volume":"24","author":"Nijboer","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"2021111720274145700_BST-2017-0017CC89","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/ana.22413","article-title":"Targeting the p53 pathway to protect the neonatal ischemic brain","volume":"70","author":"Nijboer","year":"2011","journal-title":"Ann. Neurol."},{"key":"2021111720274145700_BST-2017-0017CC90","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/sj.jcbfm.9600413","article-title":"Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic\u2013ischaemic injury","volume":"27","author":"Pirianov","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2021111720274145700_BST-2017-0017CC91","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.neuroscience.2012.05.002","article-title":"Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia\u2013ischemia","volume":"219","author":"Chavez-Valdez","year":"2012","journal-title":"Neuroscience"},{"key":"2021111720274145700_BST-2017-0017CC92","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ijdevneu.2015.11.007","article-title":"Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia-ischemia","volume":"48","author":"Chavez-Valdez","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"2021111720274145700_BST-2017-0017CC93","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/sj.cdd.4402200","article-title":"Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium","volume":"14","author":"H\u00f8yer-Hansen","year":"2007","journal-title":"Cell Death Differ."},{"key":"2021111720274145700_BST-2017-0017CC94","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1093\/hmg\/ddv207","article-title":"Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease","volume":"24","author":"Peng","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2021111720274145700_BST-2017-0017CC95","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1080\/15548627.2015.1132134","article-title":"Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury","volume":"12","author":"Xie","year":"2016","journal-title":"Autophagy"},{"key":"2021111720274145700_BST-2017-0017CC96","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/jnc.13851","article-title":"Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats","volume":"139","author":"Xu","year":"2016","journal-title":"J. Neurochem."},{"key":"2021111720274145700_BST-2017-0017CC97","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1083\/jcb.201006121","article-title":"NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis","volume":"191","author":"Li","year":"2010","journal-title":"J. Cell Biol."},{"key":"2021111720274145700_BST-2017-0017CC98","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.molcel.2012.10.007","article-title":"Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease","volume":"48","author":"Wei","year":"2012","journal-title":"Mol. Cell"},{"key":"2021111720274145700_BST-2017-0017CC99","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3390\/ijms17030327","article-title":"Endoplasmic reticulum stress and associated ROS","volume":"17","author":"Zeeshan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2021111720274145700_BST-2017-0017CC100","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17524","article-title":"Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury","author":"Hu","year":"2017","journal-title":"Oncotarget"},{"key":"2021111720274145700_BST-2017-0017CC101","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.brainres.2016.06.020","article-title":"Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice","volume":"1646","author":"Bai","year":"2016","journal-title":"Brain Res."},{"key":"2021111720274145700_BST-2017-0017CC102","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/jpi.12156","article-title":"Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia","volume":"57","author":"Carloni","year":"2014","journal-title":"J. Pineal Res."}],"container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/45\/5\/1067\/431492\/bst-2017-0017c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/45\/5\/1067\/431492\/bst-2017-0017c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:26:29Z","timestamp":1637195189000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/45\/5\/1067\/66251\/Oxidative-stress-and-endoplasmic-reticulum-ER"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,22]]},"references-count":102,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,9,22]]},"published-print":{"date-parts":[[2017,10,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bst20170017","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,22]]}}}