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These include abnormally increased signaling by extracellular signal-regulated kinase 1 and kinase 2 and other mitogen-activated protein kinases, protein kinase B\/mammalian target of rapamycin complex 1 and transforming growth factor-\u03b2. Preclinical research suggests that specific inhibitors of these abnormally activated cell signaling pathways may be useful in treating human patients with this disease.<\/jats:p>","DOI":"10.1042\/bst20170236","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T01:11:05Z","timestamp":1512177065000},"page":"37-42","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cell signaling abnormalities in cardiomyopathy caused by lamin A\/C gene mutations"],"prefix":"10.1042","volume":"46","author":[{"given":"Howard J.","family":"Worman","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, U.S.A."},{"name":"Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"2021111720354034900_BST-2017-0236CC1","doi-asserted-by":"crossref","first-page":"16321","DOI":"10.1016\/S0021-9258(19)85424-8","article-title":"Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C","volume":"268","author":"Lin","year":"1993","journal-title":"J. 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