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We ask: is this definition of a gasotransmitter appropriate in the cases of nitric oxide, carbon monoxide and hydrogen sulfide (H2S) in microbes? Recent advances show that, not only do bacteria synthesise each of these gases, but the molecules also have important signalling or messenger roles in addition to their toxic effects. However, strict application of the criteria proposed for a gasotransmitter leads us to conclude that the term \u2018small molecule signalling agent\u2019, as proposed by Fukuto and others, is preferable terminology.<\/jats:p>","DOI":"10.1042\/bst20170311","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T06:35:25Z","timestamp":1536215725000},"page":"1107-1118","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as \u2018gasotransmitters\u2019 in bacteria?"],"prefix":"10.1042","volume":"46","author":[{"given":"Lauren K.","family":"Wareham","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center, Vanderbilt Eye Institute, 11420 Medical Research Building IV, 215B Garland Avenue, Nashville, TN 37232-0654, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Southam","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield S10 2TN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield S10 2TN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"2021111818150023900_BST-2017-0311CC1","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"2021111818150023900_BST-2017-0311CC2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59259-806-9_1","volume-title":"Signal Transduction and the Gasotransmitters. 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