{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:45:09Z","timestamp":1789965909923,"version":"4.0.1"},"reference-count":76,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":307,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,19]]},"abstract":"<jats:p>Restoring blood flow following an acute myocardial infarction saves lives, but results in tissue damage due to ischaemia\u2013reperfusion injury (I\/R). Ameliorating this damage is a major research goal to improve recovery and reduce subsequent morbidity due to heart failure. Both the ischaemic and reperfusion phases represent crises of cellular energy provision in which the mitochondria play a central role. This mini-review will explore the rationale and therapeutic potential of augmenting the creatine kinase (CK) energy shuttle, which constitutes the primary short-term energy buffer and transport system in the cardiomyocyte. Proof-of-principle data from several transgenic mouse models have demonstrated robust cardioprotection by either raising myocardial creatine levels or by overexpressing specific CK isoforms. The effect on cardiac function, high-energy phosphates and myocardial injury will be discussed and possible directions for future research highlighted. We conclude that the CK system represents a viable target for therapeutic intervention in I\/R injury; however, much needed translational studies will require the development of new pharmacological tools.<\/jats:p>","DOI":"10.1042\/bst20170504","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T06:41:18Z","timestamp":1537512078000},"page":"1119-1127","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The creatine kinase system as a therapeutic target for myocardial ischaemia\u2013reperfusion injury"],"prefix":"10.1042","volume":"46","author":[{"given":"Fang","family":"Cao","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine and the BHF Centre of Research Excellence, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevasti","family":"Zervou","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine and the BHF Centre of Research Excellence, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-0284","authenticated-orcid":false,"given":"Craig A.","family":"Lygate","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine and the BHF Centre of Research Excellence, University of Oxford, Oxford, U.K."},{"name":"Division of Cardiovascular Medicine, Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"2021111818134605100_BST-2017-0504CC1","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart--an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N. 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