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Adhesion is a prerequisite for neutrophil extravasation and chemoattractant-stimulated recruitment to inflammatory sites, where neutrophils phagocytose and kill microbes, release inflammatory mediators and cross-talk with other immune cells to co-ordinate the immune response in preparation for tissue repair. Many signalling proteins are critically involved in the complex signalling processes that underpin the inflammatory response and cross-talk between endothelium and leukocytes. As key regulators of cell\u2013cell and cell\u2013substratum adhesion, small GTPases (guanosine triphosphatases) act as important controls of neutrophil-endothelial cell interactions as well as neutrophil recruitment to sites of inflammation. Here, we summarise key processes that are dependent upon small GTPases in leukocytes during these early inflammatory events. We place a particular focus on the regulation of integrin-dependent events and their control by Rho and Rap family GTPases as well as their regulators during neutrophil adhesion, chemotaxis and recruitment.<\/jats:p>","DOI":"10.1042\/bst20170530","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T17:55:15Z","timestamp":1525888515000},"page":"649-658","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Small GTPase-dependent regulation of leukocyte\u2013endothelial interactions in inflammation"],"prefix":"10.1042","volume":"46","author":[{"given":"Julia Y.","family":"Chu","sequence":"first","affiliation":[{"name":"Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"McCormick","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Vermeren","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"key":"2021111818091480000_BST-2017-0530CC1","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev. 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