{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:16:00Z","timestamp":1790810160355,"version":"4.1.0"},"reference-count":84,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":172,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the present study, we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington's disease, Parkinson's disease and Alzheimer's disease; in signalling and development, in particular, in relation to Hedgehog signalling; and in cancer, with a special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.<\/jats:p>","DOI":"10.1042\/bst20180135","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T14:15:10Z","timestamp":1554128110000},"page":"517-526","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Oxysterol research: a brief review"],"prefix":"10.1042","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-6616","authenticated-orcid":false,"given":"William J.","family":"Griffiths","sequence":"first","affiliation":[{"name":"Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, Wales, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, Wales, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"2021111915525306900_BST-2018-0135CC1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1152\/physrev.2000.80.1.361","article-title":"Oxysterols: modulators of cholesterol metabolism and other processes","volume":"80","year":"2000","journal-title":"Physiol. 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