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This review will delve into the role of EVs in promoting cancer metastasis by relying on a balanced perspective that looks at challenges faced previously by extracellular vesicle biologists, current technical limitations in the field, and overlooked physiologic mechanisms that may play a confounding role. This review will also discuss how certain experimental approaches are misleading which ultimately lead to overly optimistic mechanisms that have minimally contributed to the pathophysiology of metastasis.<\/jats:p>","DOI":"10.1042\/bst20180253","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T16:26:40Z","timestamp":1547569600000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The role of extracellular vesicles in cancer microenvironment and metastasis: myths and challenges"],"prefix":"10.1042","volume":"47","author":[{"given":"Fabrice","family":"Lucien","sequence":"first","affiliation":[{"name":"Department of Urology, Mayo Clinic, Rochester, MN, U.S.A."},{"name":"Department of Physiology and Biomedical Engineering, Rochester, MN, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-1402","authenticated-orcid":false,"given":"Hon S.","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Urology, Mayo Clinic, Rochester, MN, U.S.A."},{"name":"Department of Physiology and Biomedical Engineering, Rochester, MN, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"2021111714021419000_BST-2018-0253CC1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1073\/pnas.77.1.399","article-title":"Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells","volume":"77","year":"1980","journal-title":"Proc. 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