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Glycan structures are diverse and complex; however, they have been detected and targeted in the central nervous system (CNS) by various immunohistochemical detection methods using glycan-binding proteins such as anti-glycan antibodies or lectins and\/or characterized with analytical techniques such as chromatography and mass spectrometry. The glycan structures on glycoproteins and glycolipids expressed in neural stem cells play key roles in neural development, biological processes and CNS maintenance, such as cell adhesion, signal transduction, molecular trafficking and differentiation. This brief review will highlight some of the important findings on differential glycan expression across stages of CNS cell differentiation and in pathological disorders and diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, schizophrenia and brain cancer.<\/jats:p>","DOI":"10.1042\/bst20180330","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T18:26:10Z","timestamp":1545071170000},"page":"89-100","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Understanding cellular glycan surfaces in the central nervous system"],"prefix":"10.1042","volume":"47","author":[{"given":"Sameera","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Molecular Sciences, ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ghanimi Fard","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences, ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Everest-Dass","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle H.","family":"Packer","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences, ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia"},{"name":"Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-8811","authenticated-orcid":false,"given":"Lindsay M.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences, ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"2021111714031546600_BST-2018-0330CC1","volume-title":"Glycobiology of the Nervous System","year":"2014"},{"key":"2021111714031546600_BST-2018-0330CC2","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nrm3383","article-title":"Vertebrate protein glycosylation: diversity, synthesis and function","volume":"13","year":"2012","journal-title":"Nat. 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