{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:24:34Z","timestamp":1790738674570,"version":"4.1.0"},"reference-count":62,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein\u2013protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.<\/jats:p>","DOI":"10.1042\/bst20190249","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T16:34:10Z","timestamp":1569342850000},"page":"1393-1404","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["POPDC proteins and cardiac function"],"prefix":"10.1042","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-5356","authenticated-orcid":false,"given":"Thomas","family":"Brand","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, 4th Floor ICTEM Building, Du Cane Road, London W12 0NN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"2021111915550207200_BST-2019-0249CC1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.tips.2017.11.006","article-title":"cAMP: From long-range second messenger to nanodomain signalling","volume":"39","year":"2018","journal-title":"Trends Pharmacol. 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