{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:11:28Z","timestamp":1791616288481,"version":"4.3.4"},"reference-count":99,"publisher":"Portland Press Ltd.","issue":"4","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,28]]},"abstract":"<jats:p>Planar polarity refers to cellular polarity in an orthogonal plane to apicobasal polarity, and is seen across scales from molecular distributions of proteins to tissue patterning. In many contexts it is regulated by the evolutionarily conserved \u2018core' planar polarity pathway that is essential for normal organismal development. Core planar polarity pathway components form asymmetric intercellular complexes that communicate polarity between neighbouring cells and direct polarised cell behaviours and the formation of polarised structures. The core planar polarity pathway consists of six structurally different proteins. In the fruitfly Drosophila melanogaster, where the pathway is best characterised, an intercellular homodimer of the seven-pass transmembrane protein Flamingo interacts on one side of the cell junction with the seven-pass transmembrane protein Frizzled, and on the other side with the four-pass transmembrane protein Strabismus. The cytoplasmic proteins Diego and Dishevelled are co-localised with Frizzled, and Prickle co-localises with Strabismus. Between these six components there are myriad possible molecular interactions, which could stabilise or destabilise the intercellular complexes and lead to their sorting into polarised distributions within cells. Post-translational modifications are key regulators of molecular interactions between proteins. Several post-translational modifications of core proteins have been reported to be of functional significance, in particular phosphorylation and ubiquitination. In this review, we discuss the molecular control of planar polarity and the molecular ecology of the core planar polarity intercellular complexes. Furthermore, we highlight the importance of understanding the spatial control of post-translational modifications in the establishment of planar polarity.<\/jats:p>","DOI":"10.1042\/bst20190404","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T11:52:11Z","timestamp":1598010731000},"page":"1297-1308","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins"],"prefix":"10.1042","volume":"48","author":[{"given":"Carl","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Strutt","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-4515","authenticated-orcid":false,"given":"David","family":"Strutt","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"2021111916034998400_BST-2019-0404CC1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1146\/annurev-genet-112414-055224","article-title":"Conservation of planar polarity pathway function across the animal kingdom","volume":"49","year":"2015","journal-title":"Annu. 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