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The ubiquitin system is absolutely central to this process and perturbation of its function contributes directly to the onset and progression of a wide variety of diseases, including cancer, metabolic syndromes, neurodegenerative diseases, autoimmunity, inflammatory disorders, infectious diseases, and muscle dystrophies. Whilst the individual components and the overall architecture of the ubiquitin system have been delineated in some detail, how ubiquitination might be successfully targeted, or harnessed, to develop novel therapeutic approaches to the treatment of disease, currently remains relatively poorly understood. In this review, we will provide an overview of the current status of selected small molecule ubiquitin system inhibitors. We will further discuss the unique challenges of targeting this ubiquitous and highly complex machinery, and explore and highlight potential ways in which these challenges might be met.<\/jats:p>","DOI":"10.1042\/bst20190535","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T16:52:29Z","timestamp":1584723149000},"page":"479-497","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Small molecules that target the ubiquitin system"],"prefix":"10.1042","volume":"48","author":[{"given":"Hai Qiu","family":"Wu","sequence":"first","affiliation":[{"name":"Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands"},{"name":"Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-054X","authenticated-orcid":false,"given":"Huib","family":"Ovaa","sequence":"additional","affiliation":[{"name":"Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands"},{"name":"Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"2021111915591885300_BST-2019-0535CC1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.chembiol.2018.10.022","article-title":"From discovery to bedside: targeting the ubiquitin system","volume":"26","year":"2018","journal-title":"Cell Chem. 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