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The protein is also involved in other tasks, e.g. regulation of cellular protein content, constrain of the centriolar length, chromatin remodeling at DNA double strand breaks, control of protein quality balance and cell cycle progression, which might be mediated by non-ciliary activities. OFD1 represents a paradigmatic model of a protein that performs its diverse actions according to the cell needs and depending on the subcellular localization, the cell type\/tissue and other possible factors still to be determined. An increased number of multitask protein, such as OFD1, may represent a partial explanation to human complexity, as compared with less complex organisms with an equal or slightly lower number of proteins.<\/jats:p>","DOI":"10.1042\/bst20191029","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T14:39:15Z","timestamp":1599575955000},"page":"1929-1939","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["OFD Type I syndrome: lessons learned from a rare ciliopathy"],"prefix":"10.1042","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7553-3245","authenticated-orcid":false,"given":"Manuela","family":"Morleo","sequence":"first","affiliation":[{"name":"Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-4569","authenticated-orcid":false,"given":"Brunella","family":"Franco","sequence":"additional","affiliation":[{"name":"Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy"},{"name":"Medical Genetics, Department of Translational Medical Sciences, Federico II University of Naples, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"2021111916042373300_BST-2019-1029CC1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/geno.1998.5348","article-title":"Characterization of Cxorf5 (71-7A), a novel human cDNA mapping to Xp22 and encoding a protein containing coiled-coila-helical domains","volume":"51","year":"1998","journal-title":"Genomics"},{"key":"2021111916042373300_BST-2019-1029CC2","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1086\/318802","article-title":"Identification of the gene for oral-Facial-Digital type I syndrome","volume":"68","year":"2001","journal-title":"Am. 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