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Nitric oxide (NO) as a pleiotropic molecule exerts different effects on the components of the ECM driving or inhibiting augmented angiogenesis and tumour progression and tumour cell proliferation and metastasis. These effects rely on the concentration of NO within the tumour tissue, the nature of the surrounding microenvironment and the sensitivity of resident cells to NO. In this review article, we summarize the recent findings on the correlation between the levels of NO and the ECM components towards the modulation of tumour angiogenesis in different types of cancers. These are discussed principally in the context of how NO modulates the expression of ECM proteins resulting in either the promotion or inhibition of tumour growth via tumour angiogenesis. Furthermore, the regulatory effects of individual ECM components on the expression of the NO synthase enzymes and NO production were reviewed. These findings support the current efforts for developing effective therapeutics for cancers.<\/jats:p>","DOI":"10.1042\/bst20200208","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T12:41:08Z","timestamp":1604580068000},"page":"2539-2555","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of extracellular matrix in tumour angiogenesis: the throne has NOx servants"],"prefix":"10.1042","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-5549","authenticated-orcid":false,"given":"Amir M.","family":"Alsharabasy","sequence":"first","affiliation":[{"name":"C\u00daRAM, SFI Research Centre for Medical Devices, National University of Ireland, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, Lambe Institute for Translational Medicine, School of Medicine, National University of Ireland, Costello Road, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-4933","authenticated-orcid":false,"given":"Abhay","family":"Pandit","sequence":"additional","affiliation":[{"name":"C\u00daRAM, SFI Research Centre for Medical Devices, National University of Ireland, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"2021111916054576400_BST-2020-0208CC1","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1172\/JCI42059","article-title":"Increased NOS2 predicts poor survival in estrogen receptor\u2013negative breast cancer, patients","volume":"120","year":"2010","journal-title":"J. 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