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In this article, we focus on a glycosyltransferase, \u03b11,6-fucosyltransferase (Fut8) and its product, the core fucose structure on N-glycans, and summarize the potential protective functions of this structure against emphysema and chronic obstructive pulmonary disease (COPD). Studies of FUT8 and its enzymatic product, core fucose, are becoming an emerging area of interest in various fields of research including inflammation, cancer and therapeutics. This article discusses what we can learn from studies of Fut8 and core fucose by using knockout mice or in vitro studies that were conducted by our group as well as other groups. We also include a discussion of the potential protective functions of the keratan sulfate (KS) disaccharide, namely L4, against emphysema and COPD as a glycomimetic. Glycomimetics using glycan analogs is one of the more promising therapeutics that compensate for the usual therapeutic strategy that involves targeting the genome and the proteome. These typical glycans using KS derivatives as glycomimetics, will likely become a clue to the development of novel and effective therapeutic strategies.<\/jats:p>","DOI":"10.1042\/bst20200780","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T15:41:52Z","timestamp":1614008512000},"page":"441-453","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Keratan sulfate-based glycomimetics using Langerin as a target for COPD: lessons from studies on Fut8 and core fucose"],"prefix":"10.1042","volume":"49","author":[{"given":"Yuki","family":"Ohkawa","sequence":"first","affiliation":[{"name":"Department of Glyco-Oncology and Medical Biochemistry, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Glyco-Oncology and Medical Biochemistry, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-5968","authenticated-orcid":false,"given":"Naoyuki","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Glyco-Oncology and Medical Biochemistry, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"2021111916085561300_BST-2020-0780CC1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/glycob\/cww086","article-title":"Biological roles of glycans","volume":"27","year":"2017","journal-title":"Glycobiology"},{"key":"2021111916085561300_BST-2020-0780CC2","volume-title":"Essentials of Glycobiology","author":"Varki","year":"2015"},{"key":"2021111916085561300_BST-2020-0780CC3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.sbi.2006.08.011","article-title":"Decoding sugar functions by identifying target glycoproteins","volume":"16","year":"2006","journal-title":"Curr. 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