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SEMA4D has diverse effects on immunologic processes, including immune cell proliferation, differentiation, activation, and migration, through binding to its specific membrane receptors CD72, PLXNB1, and PLXNB2. Furthermore, SEMA4D and its underlying signaling have been increasingly linked with several immunological diseases. This review focuses on the significant immunoregulatory role of SEMA4D and the associated underlying mechanisms, as well as the potential application of SEMA4D as a diagnostic marker and therapeutic target for the treatment of immunological diseases.<\/jats:p>","DOI":"10.1042\/bst20200821","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T17:48:34Z","timestamp":1618249714000},"page":"2875-2890","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The emerging roles of semaphorin4D\/CD100 in immunological diseases"],"prefix":"10.1042","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1243-9654","authenticated-orcid":false,"given":"Liu","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-4878","authenticated-orcid":false,"given":"Xiangfen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-8893","authenticated-orcid":false,"given":"Yao","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-2013","authenticated-orcid":false,"given":"Dongzhe","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-5729","authenticated-orcid":false,"given":"Dingming","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"2021111916065849600_BST-2020-0821C1","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/0092-8674(93)90625-Z","article-title":"The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules","volume":"75","year":"1993","journal-title":"Cell"},{"key":"2021111916065849600_BST-2020-0821C2","doi-asserted-by":"publisher","first-page":"6366","DOI":"10.1038\/ncomms7366","article-title":"Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis","volume":"6","year":"2015","journal-title":"Nat. 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