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The physiological and pathological impact of LRRK2 is still obscure, but accumulating evidence supports a role for LRRK2 in membrane and vesicle trafficking, mainly functioning in the endosome-recycling system, (synaptic) vesicle trafficking, autophagy, and lysosome biology. LRRK2 binds and phosphorylates key regulators of the endomembrane systems and is dynamically localized at the Golgi. The impact of LRRK2 on the Golgi may reverberate throughout the entire endomembrane system and occur in multiple intersecting pathways, including endocytosis, autophagy, and lysosomal function. This would lead to overall dysregulation of cellular homeostasis and protein catabolism, leading to neuronal dysfunction and accumulation of toxic protein species, thus underlying the possible neurotoxic effect of LRRK2 mutations causing PD.<\/jats:p>","DOI":"10.1042\/bst20201146","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T15:05:27Z","timestamp":1631113527000},"page":"2063-2072","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["LRRK2 along the Golgi and lysosome connection: a jamming situation"],"prefix":"10.1042","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5262-7903","authenticated-orcid":false,"given":"Giovanni","family":"Piccoli","sequence":"first","affiliation":[{"name":"CIBIO, Universit\u00e0 Degli Studi di Trento, Italy & Dulbecco Telethon Institute, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-6796","authenticated-orcid":false,"given":"Mattia","family":"Volta","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of L\u00fcbeck, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2021111916142365500_BST-2020-1146CC1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11910-015-0564-y","article-title":"LRRK2 pathways leading to neurodegeneration","volume":"15","year":"2015","journal-title":"Curr. 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