{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:52:16Z","timestamp":1787655136959,"version":"build-2736575974"},"reference-count":91,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,30]]},"abstract":"<jats:p>The Eyes Absent (EYA) transactivator-phosphatase proteins are important contributors to cell-fate determination processes and to the development of multiple organs. The transcriptional regulatory activity as well as the protein tyrosine phosphatase activities of the EYA proteins can independently contribute to proliferation, differentiation, morphogenesis and tissue homeostasis in different contexts. Aberrant EYA levels or activity are associated with numerous syndromic and non-syndromic developmental disorders, as well as cancers. Commensurate with the multiplicity of biochemical activities carried out by the EYA proteins, they impact upon a range of cellular signaling pathways. Here, we provide a broad overview of the roles played by EYA proteins in development, and highlight the molecular signaling pathways known to be linked with EYA-associated organ development and developmental disorders.<\/jats:p>","DOI":"10.1042\/bst20201302","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T11:35:51Z","timestamp":1625139351000},"page":"1397-1408","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Eyes Absent proteins in development and in developmental disorders"],"prefix":"10.1042","volume":"49","author":[{"given":"Upendra Kumar","family":"Soni","sequence":"first","affiliation":[{"name":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushik","family":"Roychoudhury","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-7280","authenticated-orcid":false,"given":"Rashmi S.","family":"Hegde","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"2021111916122178300_BST-2020-1302CC1","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.bbagrm.2008.10.001","article-title":"The molecular circuitry governing retinal determination","volume":"1789","year":"2009","journal-title":"Biochim. 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