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Genetically modified mouse models and cellular assays have revealed that LUBAC is also involved in embryonic development in mice. LUBAC dysfunction is associated with autoimmune diseases, myopathy, and neurodegenerative diseases in humans, but the underlying mechanisms are poorly understood. In this review, we focus on the roles of linear ubiquitin chains and LUBAC in immune and neurodegenerative diseases. We further discuss LUBAC inhibitors and their potential as therapeutics for these diseases.<\/jats:p>","DOI":"10.1042\/bst20211078","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T10:57:59Z","timestamp":1648465079000},"page":"799-811","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Linear ubiquitination in immune and neurodegenerative diseases, and beyond"],"prefix":"10.1042","volume":"50","author":[{"given":"Fuminori","family":"Tokunaga","sequence":"first","affiliation":[{"name":"Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0407-2768","authenticated-orcid":false,"given":"Fumiyo","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"2022042906562622200_BST-2021-1078CC1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1073\/pnas.72.1.11","article-title":"Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells","volume":"72","year":"1975","journal-title":"Proc. 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