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ITSN1 and 2, collectively referred to as ITSN, are implicated in many physiological and pathological processes, such as neuronal maintenance, actin cytoskeletal rearrangement, and tumor progression. ITSN is mis-regulated in many tumors, such as breast, lung, neuroblastomas, and gliomas. Altered expression of ITSN is also found in several neurodegenerative diseases, such as Down Syndrome and Alzheimer's disease. This review summarizes recent studies on ITSN and provides an overview of the function of this important family of scaffold proteins in various biological processes.<\/jats:p>","DOI":"10.1042\/bst20211241","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T12:08:10Z","timestamp":1704370090000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Intersectin \u2014 many facets of a scaffold protein"],"prefix":"10.1042","volume":"52","author":[{"given":"Mubashir","family":"Mintoo","sequence":"first","affiliation":[{"name":"1Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinodh","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"1Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-1080","authenticated-orcid":false,"given":"John P.","family":"O'Bryan","sequence":"additional","affiliation":[{"name":"1Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, U.S.A."},{"name":"2Ralph H. 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