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A sub group of these disorders are the sphingolipidoses in which sphingolipids accumulate in the lysosome. In this review, I will discuss how the study of these rare lysosomal disorders reveals unanticipated links to other rare and common human diseases using Niemann\u2013Pick disease type C as an example.<\/jats:p>","DOI":"10.1042\/bst20220711","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:21:32Z","timestamp":1697458892000},"page":"1777-1787","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The expanding boundaries of sphingolipid lysosomal storage diseases; insights from Niemann\u2013Pick disease type C"],"prefix":"10.1042","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-0403","authenticated-orcid":false,"given":"Frances M.","family":"Platt","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"2023103115360716900_BST-2022-0711CC1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41572-018-0025-4","article-title":"Lysosomal storage diseases","volume":"4","year":"2018","journal-title":"Nat. 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